Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2008
Reliability:
1 (reliable without restriction)
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2008
Report date:
2008

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
yes
Principles of method if other than guideline:
Due to the chemical structure of the test substance it was not possible to determine the partition coefficient in the non-ionised form. The pka-value of the carboxylic acid group is 3,5, the pka value of the sulfonic acid group is 0,6. The Determination of the Partition Coefficient at a pH-value below 0,6 is not feasible. The partition coefficient was determined in the ionised form.
The Batch Equilibrium Method is technically not feasible since the required pH value which has to be adjustified according guideline cannot be realized.
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
< 0.3
Temp.:
23 °C
pH:
6 - 8
Details on results:
Due to the chemical structure of the test substance it was not possible to determine the partition coefficient in the non-ionised form. The pka-value of the carboxylic acid group is 3,5, the pka value of the sulfonic acid group is 0,6. The Determination of the Partition Coefficient at a pH-value below 0,6 is not feasible. The partition coefficient of the substance under the experimental conditions was <0.3 (less than the lowest standard 2 -Butanone).

Applicant's summary and conclusion

Conclusions:
The substance does not have a relevant bioaccumulation. This is also in correlation to the chemical structure (salt).