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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
other: company data
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Qualifier:
no guideline followed
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
not specified
Principles of method if other than guideline:
The method describes a procedure to determine the water solubility of a solid by the weight of an exact known quantity of the product dissolving it in a known volume of water at a fixed temperature.
GLP compliance:
no
Type of method:
flask method
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: SA Dabeer (Lot No. 41401/1A0314)
- Expiration date of the lot/batch: 2019-09-16
- Purity test date: 2016-09-16

TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: The substance is produced as aqueous solution. Therefore, to determine water solubility, firstly, solid substance was obtained by spray drying process until formation of microgranules.

FORM AS APPLIED IN THE TEST (if different from that of starting material): solid (microgranules)
Key result
Water solubility:
> 909 - < 1 000 g/L
Conc. based on:
test mat. (dissolved fraction)
Loading of aqueous phase:
0.1 g/L
Incubation duration:
>= 10 min
Temp.:
20 °C
pH:
> 6 - < 7
Water solubility:
> 588 g/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
> 6 - < 7
Remarks on result:
not measured/tested
Remarks:
calculated based on known density and typical concentration of the commercial product as aqueous solution.
Details on results:
Details on supporting result:
The water solubility of the substance is at least 43% w/w, based on the knowledge of the long term stability of the commercially available product Dabquel Complex Ca L (43% HGA: Ca aqueous solution).
(as density = 1.367 kg/l --> solubility > 588 g/l)
Conclusions:
The water solubility of of the commercial HGA:Ca (as aqueous solution) is at least 588 g/L.
The water solubility determined by flask method is expressed as solubility range 909 - 1000 g/L (at 20 °C).
Executive summary:

Based on the known stability of the commercially available product, the water solubility of HGA:Ca is at least 588 g/L (calculated using density of 1.367 g/L and concentration of 43 % in water). The water solubility of solid test material that was prepared from the aqueous solution by spray drying process until formation of microgranules was determined by flask method. The result is expressed as a solubility range ( 1000g/L > solubility > 909g/L).

Description of key information

Based on the known stability of the commercially available product, the water solubility of HGA:Ca is at least 588 g/L (calculated using density of 1.367 g/L and concentration of 43 % in water).

Since the HGA:Ca is produced as aqueous solution, solid test material was prepared from the aqueous solution by spray drying process until formation of microgranules.

The water solubility was then determined by flask method. The result is expressed as a solubility range ( 1000g/L > solubility > 909g/L).

water solubility of HGA:Ca is at least 588 g/L (calculated using density of 1.367 g/L and concentration of 43 % in water). The water solubility of solid test material that was prepared from the aqueous solution by spray drying process until formation of microgranules was determined by flask method. The result is expressed as a solubility range ( 1000g/L > solubility > 909g/L).

Based on the known stability of the commercially available product, the water solubility of HGA:Ca is at least 588 g/L (calculated using density of 1.367 g/L and concentration of 43 % in water). The water solubility of solid test material that was prepared from the aqueous solution by spray drying process until formation of microgranules was determined by flask method. The result is expressed as a solubility range ( 1000g/L > solubility > 909g/L).

Key value for chemical safety assessment

Water solubility:
909 g/L
at the temperature of:
20 °C

Additional information

Based on the known stability of the commercially available product, the water solubility of HGA:Ca is at least 588 g/L (calculated using density of 1.367 g/L and concentration of 43 % in water). Since HGA:Ca is produced as aqueous solution, solid test material was prepared from the aqueous solution by evaporation at room temperature in a dissication chamber. Water solubility was then determined by flask method. The result is expressed as a solubility range ( 1000g/L > solubility > 909g/L).