Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 253-326-2 | CAS number: 37052-78-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 31 October 1984 - 14 November 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 1,3-dihydro-5-methoxy-2H-benzimidazole-2-thione
- EC Number:
- 253-326-2
- EC Name:
- 1,3-dihydro-5-methoxy-2H-benzimidazole-2-thione
- Cas Number:
- 37052-78-1
- Molecular formula:
- C8H8N2OS
- IUPAC Name:
- 5-methoxy-1,3-dihydro-2H-benzimidazole-2-thione
Constituent 1
- Specific details on test material used for the study:
- Batch: 13M 2163
Assay: 98,8%
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- On arrival at the laboratory and before assignment to this study, the rats were subjected to a visual inspection. Any animal showing signs of disability was excluded. The animals were acclimatised to laboratory conditions for at least 3 days.
The rats were kept 2 in a cage in transparent Macrolon® cages, measuring approximately 40x20 cm.
The air was changed about 15 times per hour via a centrally placed air intake and two peripheral ventilators. Target values for temperature and humidity were 18-22 degrees C and 40-70%, respectively. Recorded values were within the stipulated limits.
The animal rooms were illuminated by artificial light from fluorescent tubes on a 12-hour light/dark cycle.
The animals were fasted overnight (approximately 16 hours) before dosing and for approximately 3 hours after dosing, but otherwise they had free access to feed. Food consumption during the study was not measured. The animals had free access to municipal tap water for human consumption throughout the study.
The feed is analysed regularly for nutrients and both feed and water regularly for chemical and microbial contaminants, according to current written standard operation procedures.
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- 250, 500 and 750 mg/kg body weight
- No. of animals per sex per dose:
- The study included 3 groups of animals, with 6 males in each.
- Control animals:
- no
- Details on study design:
- All animals were weighed immediately before dosing. Surviving animals were weighed on days 1, 2, 3, 4, 7 and 14.
The animals were observed and clinical signs and mortality recorded at least once during the intervals 0-1,1-3, 3-6 and 6-24 hours and then daily up to 14 days after dosing.
Results and discussion
- Preliminary study:
- . In the dose finding phase the results showed that it was not relevant to include a dose higher than 750 mg/kg in the main study.
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- approximate LD50
- Effect level:
- > 750 - <= 1 000 mg/kg bw
- Mortality:
- No deaths occurred at the dose levels 250 and 500 mg/kg. 2 of 6 animals died on day 2 at the dose level 750 mg/kg
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Evident toxicity in rats at a dose of 750 - 1,000 mg/kg
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.