Registration Dossier
Registration Dossier
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EC number: 246-730-5 | CAS number: 25198-22-5
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
LOEC = 1.5 mg/l
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 1.5 mg/L
Additional information
No studies on long-term toxicity to aquatic invertebrates are available for the substance in itself.
Nevertheless two studies were conducted with an analogue molecule, with a different salification of the same core structure (Similar Substance 01). Further information are reported in the Read Across justification attached to section 13.
Different available tests may be valuable that gives information on long term toxicity to Daphnia.
The toxicity of the test substance to invertebrates was determined in two different tests, considered for the assessment in a weight of evidence approach, according to the Short Term Methods for Estimating the Chronic Toxicity of Effluentas and Receiving Waters to Freshwater Organisms, USEPA, 1985 (EPA/600/4-85/014).
The tests were both performed at four different concentrations: 1.5, 4.5, 9, 15 mg/l. Ten test organisms were exposed to each treatment in individual test chambers. Test solutions were renewed on days two and five with reproduction counts made at that time.
The LOEC value calculated in the first experiment was = 1.5 mg/l, while the NOEC calculated in the second test was = 15 mg/l. In a protective manner LOEC = 1.5 mg/l was considered the key value for the chemical safety assessment.
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