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EC number: 280-898-0 | CAS number: 83803-79-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary source.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Sub acute study for Disodium 4,4'-bis[(4-anilino-6-morpholino-1,3,5-triazin-2- yl)amino]stilbene-2,2'-disulfonate
- Author:
- OECD SIDS, SIAM 21
- Year:
- 2 005
- Bibliographic source:
- Sub acute study for Disodium 4,4'-bis[(4-anilino-6-morpholino-1,3,5-triazin-2- yl)amino]stilbene-2,2'-disulfonate, OECD SIDS, SIAM 21, October 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mention below
- Principles of method if other than guideline:
- To evaluate the toxic effect of Disodium 4,4'-bis[(4-anilino-6-morpholino-1,3,5-triazin-2- yl)amino]stilbene-2,2'-disulfonate in rats by oral gavage for 2 years.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Disodium 4,4'-bis[(4-anilino-6-morpholino-1,3,5-triazin-2-yl)amino]stilbene-2,2'-disulphonate
- EC Number:
- 240-245-2
- EC Name:
- Disodium 4,4'-bis[(4-anilino-6-morpholino-1,3,5-triazin-2-yl)amino]stilbene-2,2'-disulphonate
- Cas Number:
- 16090-02-1
- Molecular formula:
- C40H40N12O8S2.2Na
- IUPAC Name:
- disodium 4,4'-bis[(4-anilino-6-morpholino-1,3,5-triazin-2-yl)amino]stilbene-2,2'-disulphonate
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):disodium 4,4'-bis[(4-anilino-6-morpholino-1,3,5-triazin-2-yl)amino]stilbene-2,2'-disulphonate- Molecular formula ; C40H40N12O8S2.2Na- Molecular weight ; 924.928gm/mol- Substance type:Organic
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Details on route of administration:
- Not specified
- Vehicle:
- not specified
- Details on oral exposure:
- Not specified
- Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- Not specified
- Duration of treatment / exposure:
- 2 years
- Frequency of treatment:
- Not specified
Doses / concentrations
- Remarks:
- 0,51,71 and 524 and 791 mg/kg bw/day for males and females, respectively
- No. of animals per sex per dose:
- Not specified
- Control animals:
- not specified
- Details on study design:
- Not specified
- Positive control:
- Not specified
Examinations
- Observations and examinations performed and frequency:
- Observations and examinations performed & frequencyCAGE SIDE OBSERVATIONS: Yes DETAILED CLINICAL OBSERVATIONS: Yes BODY WEIGHT: Not specified FOOD CONSUMPTION AND COMPOUND INTAKE (if feeding study):- Food consumption for each animal determined and mean daily diet consumption calculated as g food/kg body weight/day: Not specified- Compound intake calculated as time-weighted averages from the consumption and body weight gain data: Not specifiedFOOD EFFICIENCY:- Body weight gain in kg/food consumption in kg per unit time X 100 calculated as time-weighted averages from the consumption and body weight gain data: Not specifiedWATER CONSUMPTION AND COMPOUND INTAKE (if drinking water study): Not specifiedOPHTHALMOSCOPIC EXAMINATION: Not specifiedHAEMATOLOGY: Yes CLINICAL CHEMISTRY: Yes URINALYSIS: Not specifiedNEUROBEHAVIOURAL EXAMINATION: Not specifiedOTHER:
- Sacrifice and pathology:
- Sacrifice and pathologyGROSS PATHOLOGY: Not specifiedHISTOPATHOLOGY: Yes
- Other examinations:
- Not specified
- Statistics:
- Not specified
Results and discussion
Results of examinations
- Clinical signs:
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- no effects observed
- Description (incidence and severity):
- No significant effect were observed at the at all dose level 0,51,71 and 524 and 791 mg/kg bw/day for males and females, respectively in treated group compare to control
- Clinical biochemistry findings:
- no effects observed
- Description (incidence and severity):
- No significant effect were observed at the at all dose level 0,51,71 and 524 and 791 mg/kg bw/day for males and females, respectively in treated group compare to control
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- effects observed, treatment-related
- Description (incidence and severity):
- Significant effect were observed on the kidney weight of dose level 524 and 791 mg/kg bw/day for males and females, respectively in treated group compare to control.
- Gross pathological findings:
- not specified
- Neuropathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- no effects observed
- Description (incidence and severity):
- No significant effect were observed at the at all dose level 0,51,71 and 524 and 791 mg/kg bw/day for males and females, respectively in treated group compare to control.
- Histopathological findings: neoplastic:
- not specified
- Other effects:
- not specified
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 524 other: mg/kg bw/day
- Based on:
- test mat.
- Sex:
- male
- Basis for effect level:
- other: No significant effects were observed at the clinical sign, Hematology, clinical chemistry and histopathology
- Remarks on result:
- other: No toxic effect were observed
- Dose descriptor:
- NOAEL
- Effect level:
- 791 other: mg/kg bw/day
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: No significant effects were observed at the clinical sign, Hematology, clinical chemistry and histopathology
- Remarks on result:
- other: No toxic effect were observed
Target system / organ toxicity
- Critical effects observed:
- not specified
- System:
- other: not specified
- Organ:
- not specified
- Treatment related:
- not specified
- Dose response relationship:
- not specified
- Relevant for humans:
- not specified
Applicant's summary and conclusion
- Conclusions:
- NOAEL was considered to be 524 and 791 mg/kg bw/day for males and females rats , respectively in rats by oral route for Disodium 4,4'-bis[(4-anilino-6-morpholino-1,3,5-triazin-2-yl)amino]stilbene-2,2'-disulfonate for 2 years study.
- Executive summary:
In a repeated dose toxicity studies forDisodium 4,4'-bis[(4-anilino-6-morpholino-1,3,5-triazin-2-yl)amino] stilbene-2,2'-disulfonate in male and female rats for vwas evaluated for its toxic effect. The test substance was exposed at the concentration of0,51,71 and 524 and 791 mg/kg bw/day for males and females, respectively for 28 days. The animals were observed for clinical sign, Hematology, clinical chemistry, organ weight and histopathology. As though a significant were observed on the kidney weight of dose level 524 and 791 mg/kg bw/day for males and females, respectively in treated group compare to control but no effect observed in the histopathology of kidney. No significant effects were observed at the clinical sign, Hematology, clinical chemistry and histopathology at all dose level. Therefore NOAEL was considered to be 524 and 791 mg/kg bw/day for males and females, respectively for 2 years study for Disodium 4,4'-bis[(4-anilino-6-morpholino-1,3,5-triazin-2-yl)amino] stilbene-2,2'-disulfonate.
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