Registration Dossier
Registration Dossier
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EC number: 267-041-6 | CAS number: 67763-18-2
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects on aquatic invertebrates up to the limit of water solubility, read across.
Key value for chemical safety assessment
Additional information
Data on the acute toxicity of Diisooctadecyl malate (CAS 67763-18-2) to aquatic invertebrates are not available. The assessment was therefore based on a study conducted with the structurally similar substance bis(C12-C13)alkyl-2-hydroxybutandioate (CAS 149144-85-4) as part of a read-across approach, which is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Further justification is given within the overall summary chapter 6.1 and within the analogue justification section 13.
One study evaluating the acute toxicity of bis(C12-C13)alkyl-2-hydroxybutandioate (CAS 149144-85-4) to aquatic invertebrates is available (Biffi, 1993). This test was performed according to OECD 202, under GLP conditions. Daphnia magna was exposed to the test substance at a nominal test substance concentration of 100 mg/L for a period of 48 hours. The test was performed under static exposure conditions. No immobilisation of Daphnids was observed. The resulting EC50 (48 h) was determined to be >100 mg/L (NOEC (48 h): ≥100 mg/L) based on the nominal test substance concentration.
Based on the available result from one structurally related source substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that Diisooctadecyl malate is not acutely toxic to aquatic invertebrates up to the limit of water solubility.
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