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EC number: 205-371-4 | CAS number: 139-66-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Data is from peer-reviewed journal
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- HENRY F. SMYTH, JR., Ph.D., CHARLES P. CARPENTER, Ph.D., CARROL S. WEIL, M.A., URBAN0 C. POZZANI, M.S., and JEAN. A. STRIEGEL, B.S.
- Year:
- 1 962
- Bibliographic source:
- American Industrial Hygiene Association Journal, V.23:2, pages 95-107 1962
- Reference Type:
- other: authoritative database
- Title:
- Eye irritation study for Diphenyl sulphide/ Phenyl Sulfide (CAS No. 139-66-2)
- Author:
- GSBL
- Year:
- 2 018
- Bibliographic source:
- GSBL, Joint Substance Data Pool of the German Federal Government and the German Federal States, 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- The study was conducted to evaluate the acute eye irritation potential of Diphenyl sulphide/ Phenyl Sulfide (CAS No. 139-66-2) in albino rabbits.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Diphenyl sulphide
- EC Number:
- 205-371-4
- EC Name:
- Diphenyl sulphide
- Cas Number:
- 139-66-2
- Molecular formula:
- C12H10S
- IUPAC Name:
- (phenylsulfanyl)benzene
- Test material form:
- liquid
- Details on test material:
- Name of test material (as cited in study report): Diphenyl sulphide
Molecular formula:C12H10S
Molecular weight:186.277 g/mol
Smiles : c1(Sc2ccccc2)ccccc1
InChI : 1S/C12H10S/c1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h1-10H
Substance Type: Organic
Physical State: Liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Phenyl sulfide
- Molecular formula: C12H10S
- Molecular weight: 186.277 g/mole
- Substance type: Organic
- Physical state: Liquid
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Albino New Zealand
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.5 to 3.5 kg
- Sex: Male
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
- Concentration (if solution): undiluted chemical
VEHICLE (not used)
- Amount(s) applied (volume or weight with unit): No data
- Concentration (if solution): No data
- Lot/batch no. (if required): No data
- Purity: No data - Duration of treatment / exposure:
- No data available
- Observation period (in vivo):
- No data available
- Number of animals or in vitro replicates:
- No data available
- Details on study design:
- TEST SITE
- Area of exposure: Eye
- % coverage: No data available
- Type of wrap if used: No data available
REMOVAL OF TEST SUBSTANCE
- Washing (if done): No data available
- Time after start of exposure: No data available
SCORING SYSTEM:
A 10- grade ordinal series and is based upon the degree of corneal necrosis that results from instillation of various volumes and concentrations of chemical. Grade 1 indicates at most a very small area of necrosis resulting from 0.5 ml of undiluted chemical in the eye. Grade 5 indicates a so-called severe burn from 0.005 ml, and Grade 10 indicates a severe burn from 0.5 ml of a 1% solution in water or propylene glycol.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: corneal necrosis
- Basis:
- mean
- Score:
- 2
- Max. score:
- 10
- Reversibility:
- not specified
- Remarks on result:
- probability of mild irritation
Applicant's summary and conclusion
- Interpretation of results:
- other: Not irritating
- Conclusions:
- The test substance Diphenyl sulphide/ Phenyl Sulfide (CAS No. 139-66-2) was considered to be not irritating to the rabbit eyes.
- Executive summary:
The study was conducted to evaluate the acute eye irritation potential of Diphenyl sulphide/ Phenyl Sulfide (CAS No. 139-66-2) in albino rabbits. A score of 2, indicates at most a very small area of necrosis resulting from 0.5 ml of undiluted chemical in the eye. Hence, it was concluded that test substance Diphenyl sulphide/ Phenyl Sulfide (CAS No. 139 -66 -2) was considered to be not irritating to the rabbit eyes.
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