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Diss Factsheets
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EC number: 205-371-4 | CAS number: 139-66-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Data is from peer-reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Salmonella mutagenicity tests: IV. Results from the testing of 300 chemicals.
- Author:
- Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K.
- Year:
- 1 988
- Bibliographic source:
- Environ Mol Mutagen. 1988;11 Suppl 12:1-157.
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Bacterial reverse gene mutation assay was performed to evaluate the mutagenic potential of the test material allyl propyl disulfide (CAS No. 2179-59-1).
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Allyl propyl disulphide
- EC Number:
- 218-550-7
- EC Name:
- Allyl propyl disulphide
- Cas Number:
- 2179-59-1
- Molecular formula:
- C6H12S2
- IUPAC Name:
- Allyl propyl disulphide
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Name of test material (as cited in study report): Allyl propyl disulphide
Molecular formula:C6H12S2
Molecular weight:148.2928 g/mol
Substance Type: Organic
Physical State: Liquid
Method
- Target gene:
- Histidine
Species / strain
- Species / strain / cell type:
- S. typhimurium, other: TA97, TA98, TA100, TA102, TA1535, TA1537
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with and without
- Metabolic activation system:
- liver S-9 from Aroclor-induced male Sprague-Dawley rats and Syrian hamsters
- Test concentrations with justification for top dose:
- Up to 333 microgram/plate
- Vehicle / solvent:
- No data available
Controls
- Untreated negative controls:
- not specified
- Negative solvent / vehicle controls:
- not specified
- True negative controls:
- not specified
- Positive controls:
- not specified
- Positive control substance:
- not specified
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: preincubation
- Rationale for test conditions:
- No data available
- Evaluation criteria:
- No data available
- Statistics:
- No data available
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other: TA97, TA98, TA100, TA102, TA1535, TA1537
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: no mutagenic potential
Applicant's summary and conclusion
- Conclusions:
- In an Ames test using Salmonella typhimurium strains TA97, TA98, TA100, TA102, TA1535, TA1537 with and without S9 activation, doses up to 333 microgram/plate allyl propyl disulfide (CAS No. 2179-59-1) were not mutagenic.
- Executive summary:
The bacterial reverse gene mutation assay was performed to evaluate the mutagenic potential of the test material allyl propyl disulfide (CAS No. 2179-59-1). The chemical was tested for mutagenicity, in Salmonella typhimurium, using a preincubation protocol.The test was performed in the absence of exogenous metabolic activation, and in the presence of liver S-9 from Aroclor-induced male Sprague-Dawley rats and Syrian hamsters. In an Ames test using Salmonella typhimurium strains TA97, TA98, TA100, TA102, TA1535, TA1537 with and without S9 activation, doses up to 333 microg/plate allyl propyl disulfide (CAS No. 2179-59-1) were not mutagenic. Hence, according to CLP criteria, it can be concluded that allyl propyl disulfide (CAS No. 2179-59-1) was non genotoxic.
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