Registration Dossier

Diss Factsheets

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Version / remarks:
Adopted 27.07.95
GLP compliance:
no
Type of method:
flask method
Partition coefficient type:
octanol-water
Analytical method:
photometric method
Type:
Pow
Partition coefficient:
0.033
Temp.:
20 °C
pH:
6.3
Remarks on result:
other: Average Pow
Type:
log Pow
Partition coefficient:
-1.489
Temp.:
20 °C
pH:
6.3
Remarks on result:
other: Average log Pow

At 96 hours values reached equilibrium, and so this value was considered for final calculations making duplicate determinations of every ratio o/w.

Concentration of mother solution: W1 = 0.0404 g / 100 ml = 0.4040 g/l

Ratio o/w Water phase n-octanol phase Pow log Pow
Conc. (g/l) Conc. (g/l)
70/30 0.3931 0.0109 0.0279 -1.5551
70/30 0.3898 0.0109 0.0281 - 1.5515
50/50 0.3920 0.0120 0.0307 - 1.5125
50/50 0.3876 0.0120 0.0311 - 1.5076
30/70 0.3887 0.0153 0.0394 - 1.4041
30/70 0.3887 0.0153 0.0394 - 1.4041
pH of the test solution 6.30
Average Pow 0.0328
Average log Pow -1.4891
Std. dev. Pow 0.006
Conclusions:
Average Pow: 0.0328 at 20 °C and at pH of 6.30
Average log Pow: -1.4891 at 20 °C and at pH of 6.30
Executive summary:

Method

Partition coefficient was determined by means of shake flask method as per recommendations of OECD 107. Partition coefficient (P) is defined as the ratio of the equilibrium concentrations of a dissolved substance in a two-phase system consisting in two largely immiscible solvents.

Result

Study conducted at 20 °C and at pH of 6.30.

Average Pow: 0.0328

Average log Pow: -1.4891

Description of key information

-1.4891

Key value for chemical safety assessment

Log Kow (Log Pow):
-1.489
at the temperature of:
20 °C

Additional information

Shake flask method - OECD 107