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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Remarks:
Although the values recorded are outside of the applicability domain for the test method, the results can be considered as reliable and representative for the tested substance. The study outcomes are indicative of a high affinity with the water phase, respect than the octanol one.
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Version / remarks:
adopted 27.07.95
GLP compliance:
no
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water
Analytical method:
photometric method
Type:
Pow
Partition coefficient:
ca. 0.004
Temp.:
20 °C
pH:
ca. 6.42
Remarks on result:
other: Standard deviation Pow = 0.0003
Type:
log Pow
Partition coefficient:
ca. -2.459
Temp.:
20 °C
pH:
ca. 6.42
Remarks on result:
other: Standard deviation log Pow = 0.044
Conclusions:
logPow = -2.4586 at 20 °C and at pH of 6.42.
Executive summary:

Method:

Partition coefficient was determined by means of shake flask method as per recommendations of OECD 107 Guideline. Partition coefficient (P) is defined as the ratio of the equilibrium concentrations of a dissolved substance in a two-phase system consisting in two largely immiscible solvents.

Result:

Study conducted at 20 °C and at pH of 6.42.

The average Pow is 0.0035.

The average logPow is -2.4586.

Description of key information

logPow: -2.4586 at 20 °C and at pH of 6.42

Key value for chemical safety assessment

Log Kow (Log Pow):
-2.459
at the temperature of:
20 °C

Additional information

Partition coefficient was determined by means of shake flask method as per recommendations of OECD 107 Guideline.