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EC number: 943-403-5 | CAS number: -
This study was performed to investigate the potential of the substance to induce gene mutations according to the plate incorporation test using the Salmonella typhimurium strains TA 1535, TA 1537, TA 1538, TA 98 and TA 100.
The assay was performed in two independent experiments, using identical procedures, both with and without liver microsomal activation. Each concentration, including the controls, was tested in triplicate. The test article was tested at the following concentrations:
10.0; 100.0; 333.3; 1000.0; and 5000.0 µg/p1ate.
No toxic effects, evidenced by a reduction in the number of spontaneous revertants, occurred in any of the test groups with and without metabolic activation.
The plates incubated with the test article showed normal background growth up to 5000.0 ug/plate with and without S9 mix in all strains used.
Up to the highest investigated dose, a significant and reproducible dose-dependent increase in revertant colony numbers was obtained in the Salmonella typhimurium strains TA 1537, TA 1538, TA 98, and TA 100. The presence of liver microsomal activation did not influence these findings. However, the positive response in strain TA 98 was not reproduced in the independent experiment in the presence of S9 mix.
Appropriate reference mutagens were used as positive controls and showed a distinct increase of induced revertant colonies.
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