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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Hydrolysis

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
hydrolysis
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer reviewed journal, HSDB and PubChem authoritative database
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Determination of half lives of chemical Methyl methanesulfonate (CAS no. 66-27-3).
GLP compliance:
not specified
Specific details on test material used for the study:
- Name of test material (as cited in study report): Methyl methanesulfonate
- Molecular formula (if other than submission substance): C2H6O3S
- Molecular weight (if other than submission substance): 110.1324 g/mol
- Smiles notation (if other than submission substance): COS(=O)(=O)C
- InChI: 1S/C2H6O3S/c1-5-6(2,3)4/h1-2H3
- Substance type: Organic
- Physical state: Liquid
Radiolabelling:
not specified
Analytical monitoring:
not specified
Estimation method (if used):
No data available
Temp.:
25 °C
Remarks:
Other details not known
Temp.:
20 °C
Remarks:
Other details not known
Positive controls:
not specified
Negative controls:
not specified
Transformation products:
not specified
Key result
Temp.:
25 °C
DT50:
4.56 h
Type:
not specified
Remarks on result:
other: Other details not known
Key result
DT50:
9.66 h
Type:
not specified
Remarks on result:
other: temperature not known
Key result
Temp.:
20 °C
DT50:
77 h
Type:
not specified
Remarks on result:
other: Other details not known
Validity criteria fulfilled:
not specified
Conclusions:
The half-life of Methyl methanesulfonate was determined to be 4.56 h (at 20ᵒC), 9.66 hrs and 77 hrs (at 25ᵒC) respectively, indicates that the chemical Methyl methanesulfonate undergoes moderate to slow hydrolysis in water.
Executive summary:

The half-life of Methyl methanesulfonate (CAS no. 66 -27 -3) was determined to be 4.56 h (at 20ᵒC), 9.66 hrs and 77 hrs (at 25ᵒC) respectively, indicates that the chemical Methyl methanesulfonate undergoes moderate to slow hydrolysis in water.

Description of key information

The half-life of Methyl methanesulfonate (CAS no. 66 -27 -3) was determined to be 4.56 h (at 20ᵒC), 9.66 hrs and 77 hrs (at 25ᵒC) respectively, indicates that the chemical Methyl methanesulfonate undergoes moderate to slow hydrolysis in water.

Key value for chemical safety assessment

Half-life for hydrolysis:
77 h
at the temperature of:
25 °C

Additional information

Experimental key studyfor the target chemical Methyl methanesulfonate (CAS no. 66-27-3) and supporting study for its structurally similar read across substance were reviewed for hydrolysis end point which are summarized as below:

 

In an experimental key study from peer reviewed journal (Arthur R et. al; 1987) and authoritative database (HSDB and PubChem, 2017), the half-life of Methyl methanesulfonate (CAS no. 66 -27 -3) was determined to be 4.56 h (at 20ᵒC), 9.66 hrs and 77 hrs (at 25ᵒC) respectively.

 

For the read across chemical Isopropyl methanesulfonate (CAS no. 926-06-7), the half-lives of chemical Isopropyl methanesulfonate was determined to be 4.56 hrs at 25°C and 77 hrs at 20°C respectively (HSDB, 2017).

 

Thus, based on the overall reported results for target chemical Methyl methanesulfonate (from authoritative database HSDB and PubChem, 2017& from peer reviewed journal) and the study for the read across chemical (from authoritative database HSDB, 2017), it can be concluded that the test substance Methyl methanesulfonate can be considered to undergoes moderate to slow hydrolysis in water.