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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Data is from experimental study performed using standard guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
GLP compliance:
no
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
5.2
Temp.:
25 °C
pH:
6.6
Details on results:
The Partition coefficient (Pow) of the test substance was observed to be 5.2 at 25°C.
Conclusions:
The partition coefficient (n-octanol/water) of test substance was determined as per the HPLC method (OECD Guideline-117). The Log Pow value was determined to be 5.2 at 25°C.
Executive summary:

The partition Coefficient n-octanol/water of the test substance was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals. The Log Pow value of test chemical was determined to be 5.2 at 25°C.

Description of key information

The partition Coefficient n-octanol/water of the test substance was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals. The Log Pow value of test chemical was determined to be 5.2 at 25°C.

Key value for chemical safety assessment

Log Kow (Log Pow):
5.2
at the temperature of:
25 °C

Additional information

Various experimental and predicted data has been summarized as below for the determination of partition Coefficient of test chemical.

The partition Coefficient n-octanol/water of the test substance was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals. The Log Pow value of test chemical was determined to be 5.2 at 25°C.

The partition coefficient (log Pow) value of the test substance was estimated to be 5.07 using OPERA V1.02. Based on this value, the test chemical can be considered to be hydrophobic in nature.

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