Registration Dossier

Ecotoxicological information

Short-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

By QSAR Toolbox version 3.3  predicted model the short term toxicity (LC50) in Brachydanio rerio (new name: Danio rerio) fish was estimated to be 121.41493988 mg/l for 96 hrs in static condition for test substance 2-nitro-p-phenylenediamine with mortality effects. 

Key value for chemical safety assessment

LC50 for freshwater fish:
121.414 mg/L

Additional information

Weight of evidence studies summarised from two predicted model as followed:

1)QSAR Toolbox version 3.3(Sustainability Support Services (Europe) AB):

By QSAR Toolbox version 3.3 predicted model the short term toxicity (LC50) in Brachydanio rerio (new name: Danio rerio) fish was estimated to be 121.41493988 mg/l for 96 hrs in static condition for test substance 2-nitro-p-phenylenediamine with mortality effects.

2) ECOSAR Version 1.10 by Environmental Protection Agency (EPA):

Based on the QSAR prediction done using the EPI Suite ECOSAR version 1.10, the 96 hours LC50 was estimated to be2515.306 mg/L on fish for substance 2-nitro-p-phenylenediamine with mortality effects.

Thus based on this available values it can be concluded that the substance 2-nitro-p-phenylenediamine shall not be classified as hazardous for fish as per the criteria of CLP regulation.