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Diss Factsheets
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EC number: 215-202-6 | CAS number: 1313-13-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
A single dose of manganese dioxide (250 mg/kg intratracheal administration) in rabbits caused severe degenerative changes in the seminiferous tubules and these effects led to sterility. This effect did not occur immediately but developed slowly over the period of 4~8 months following the exposure. A LOAEL was 250 mg/kg/day in male rabbit (see Seth at all, Effects of manganese on rabbits testes, Environmental and physiological biochemistry, 3(6): 263-267, 1973 mentioned in SIDS Dossier of MnO2 approved at SIAM 25 (17 -18 October 2007).
Short description of key information:
The available information on animals suggests that manganese dioxide causes probably negative effects on fertility but based on human data no classification is reasonably possible. The data on human male are equivocal and there are no data for female (see section 7.10 IUCLID).
Effects on developmental toxicity
Description of key information
The available information on animal suggests that manganese dioxide shows developmental toxicity (locomotory deseases in the offspring) but there are no sufficient data for classification.
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available (further information necessary)
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
As reported in SIDS Dossier of MnO2 approved at SIAM 25 (17 -18 October 2007) with reference to Lown et all, Effects on the postnatal development of the mouse of preconception, postconception and/or suckling exposure to manganese via maternal inhalation exposure to MnO2 dust,Neurotoxicology,5(1): 119-129, 1984 effects on pup body weight and locomotor activity were observed on mice after inhalation exposure of of 61 mg/m3/day.Female mice were exposed either to MnO2 dust (7 hours/day, 5 days/week) or filtered air (control group) for 16 weeks prior to conception. Compared to control mothers, mothers exposed to MnO2 prior to conception produced significantly larger litters. Prenatal exposure resulted in reduced neonatal activity scores and retarded offspring growth that persisted into adulthood. The study cannot be used for a quantitative risk assessment, as only one exposure condition was tested.
Justification for classification or non-classification
Regarding fertility, the available information on animals suggests that manganese dioxide causes probably negative effects on fertility but based on human data no classification is reasonably possible. The data on human male are equivocal and there are no data for female (See section 7.10 IUCLID). MnO2 is not classified for toxicity to reproduction according to annex VI of CLP Regulation (EC n.1272/2008).
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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