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EC number: 215-202-6 | CAS number: 1313-13-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Regarding repeated dose toxicity adverse effects were observed for oral exposure (LOAEL mouse= 275 mg/kg/bw) and for inhalator exposure (LOAE = 0.7 mg/m^3). No data of repeated dose dermal toxicity are available.
However, according to CLP Regulation (EC n.1272/2008) manganese dioxide is not classified for repeated dose toxicity.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LOAEL
- 275 mg/kg bw/day
- Study duration:
- chronic
- Species:
- mouse
- Quality of whole database:
- SIDS Dossier of MnO2 approved at SIAM 25 (17 -18 October 2007)
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LOAEC
- 0.7 mg/m³
- Study duration:
- subchronic
- Species:
- monkey
- Quality of whole database:
- SIDS Dossier of MnO2 approved at SIAM 25 (17 -18 October 2007)
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Oral exposure
As reported in SIDS Dossier of MnO2 approved at SIAM 25 (17 -18 October 2007) with reference to Komura J and Sakamoto M, Short-term oral administration of several manganese compounds in mice: physiological and behavioral alterations caused by different forms of manganese.Bulletin of environmental contamination and toxicology, 46(6): 921-928, 1991, the oral LOAEL on male mice was 276 mg/kg/day based on hematological effect. The ddy mice were exposed either to a control diet containing 130 mg Mn/kg, or a diet supplemented with an additional 2000 mg Mn/kg as MnO2. The duration of treatment was 100 days. This value was confirmed by another study of chronical dietary toxicity of 1992-see Komura J and Sakamoto M, Effects of manganese forms on biogenic amines in the brain and behavioral alterations in the mouse: long-term oral administration of several manganese compounds.Environmental Research,57: 34-44,1992 reported in SIDS Dossier of MnO2 approved at SIAM 25 (17 -18 October 2007). From this study the oral LOAEL on male mice was 275 mg/kg/day based body weight gain and locomotor activity. The study was conducted feeding control and test group with 130 and 2000 mg Mn/kg, respectively, for 12 months.
Inhalator exposure
As reported in SIDS Dossier of MnO2 approved at SIAM 25 (17 -18 October 2007) with reference to Suzuki, Effects of the inhalation of manganese dioxide dust on monkey lungs.Tokushima Journal of Experimental Medicine, 25:119-125, 1978, the inhalator LOAEL on Rhesus monkey is 0.7 mg/m^3 based on inflammation in the lung. Rhesus monkeys were exposed in a repeated inhalation toxicity study to manganese dioxide dust at the concentrations of 0.7 and 3 mg Mn/m^3 for 22 hours daily for a duration of 10 months. During histological examination damages in the lung were fund. Data of chronic toxicity of manganese dioxide after inhalator exposure are supported also by a human study (see section 7.10 IUCLID).
Dermal exposure
Data on dermal repeated dose toxicity are not available.
Justification for selection of repeated dose toxicity via oral route - systemic effects endpoint:
Study conducted according to internationally accepted testing guidelines.
Justification for selection of repeated dose toxicity inhalation - systemic effects endpoint:
Study conducted according to internationally accepted testing guidelines.
Repeated dose toxicity: inhalation - systemic effects (target organ) respiratory: lung
Justification for classification or non-classification
According to CLP Regulation (EC n.1272/2008) manganese dioxide is not classified for repeated dose toxicity. According to the available data, there may be a concern deriving from inhalation exposure. However, the substance is used under strictly controlled conditions and there is no exposure to workers. Further details on guidance of safe use are reported in section 11 of IUCLID.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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