Registration Dossier
Registration Dossier
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EC number: 203-299-8 | CAS number: 105-45-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature; result presented without detailed documentation.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Fragrance raw materials monographs. Methyl acetoacetate.
- Author:
- Opdyke DLJ
- Year:
- 1 978
- Bibliographic source:
- Food Cosmet Toxicol 16: 815
- Reference Type:
- secondary source
- Title:
- Acute toxicity studies in rats, mice, rabbits and guinea pigs.
- Author:
- Moreno OM
- Year:
- 1 976
- Bibliographic source:
- Report to RIFM, 10 May 1976. Cited in Opdyke DLJ (1978). Fragrance raw materials monographs. Methyl acetoacetate. Food Cosmet Toxicol 16: 815
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Methyl acetoacetate
- EC Number:
- 203-299-8
- EC Name:
- Methyl acetoacetate
- Cas Number:
- 105-45-3
- Molecular formula:
- C5H8O3
- IUPAC Name:
- methyl 3-oxobutanoate
- Details on test material:
- - Name of test material (as cited in study report): methyl acetoacetate;
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
-no data
ENVIRONMENTAL CONDITIONS
- no data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- no data
- Duration of exposure:
- no data
- Doses:
- no data
- No. of animals per sex per dose:
- 10 animals of unknown sex.
- Control animals:
- not specified
- Details on study design:
- no data
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Remarks on result:
- other: 1/10 animals died
- Mortality:
- 5000 mg / Kg bw: One of ten animals died.
- Clinical signs:
- other: no data
- Gross pathology:
- no data
- Other findings:
- no data
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
