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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

An acute fish test with PFAEO-C18 (CAS no.: 10213-78-2) is waived as short and long-term toxicity tests with fish according to OECD 203/210 with the test substance (PFAEO-O, CAS no.: 25307-17-9 and PFAEO-C, CAS no.: 71786-60-2) are available in the registration dossier which are read across to PFAEO-C18 (see read across justification in chapter 13). This is considered to provide an adequate and reliable coverage of the key parameter(s) of the corresponding OECD TG 210 and fulfils therefore also the requirements of Column 2 of Annex VIII, Section 9.1.3, second indent.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Dose descriptor:
Effect concentration:
0.1 mg/L

Additional information

Most of the short-term toxicity fish tests were conducted in a period when no reliable specific method of analyses was available. The concentrations were therefore not analytically verified, the reliability of the results is limited because of the poor solubility of the test substances and partial sorption onto the walls of test vessels or on other surfaces like the surfaces of the test animals. Hence, most of the tests were considered to be valid with restrictions. The available data reveal a comparable toxicity independent of the chain length. The GLP study by Gancet (2009) and the study from Scheerbaum (2022) on PFAEO-C (CAS no.: 71786-60-2) are considered more reliable than the other endpoints. The study from Gancet was conducted preparing tests solutions via dilution of a concentrated stock solution and resulted in an LC50 of 0.1 mg/L. The study from Scheerbaum is performed using the WAF approach as described in OECD GD 23 and resulted in an LL50 of 241 µg/L. As a worst-case the result from Gancet is read across to PFAEO-C18. The LC50 is consequently used for risk assessment and C&L purposes.