Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-562-7 | CAS number: 108-22-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
Additional information
Isopropenyl acetate (purity 99.3%) was administered to male rats for 28 days and to female rats for 14 days prior to pairing, through the pairing and gestation periods until the F1 pups reached day 4 post partum according to OECD Guideline 421. The following dose levels were applied: 0 (control group), 50, 200 and 1000 mg/kg body weight/day. A standard dose volume of 5 mL/kg body weight with a daily adjustment to the actual body weight was used. Control animals were dosed with the vehicle alone (corn oil).
No deaths occurred in parent animals before scheduled termination. No test item-related adverse clinical signs were observed during the study at any dose level. At the dose levels of 200 and 1000 mg/kg/day, salivation was observed in males and females. This observation was considered to be a sign of discomfort caused by the test item but not an adverse effect. Food consumption was not affected by the treatment with the test item at any dose level neither in males nor in females. Body weights and body weight gain were not affected by the treatment with the test item at any dose level neither in males nor in females. Except for one female at the dose level of 50 mg/kg/day, all females were mated, became pregnant and gave birth. Mating performance, fertility, gestation and parturition were not affected by the treatment with the test item at any dose level. Weights of testes and epididymides were not affected by the treatment with the test item at any dose level. No gross lesions attributed to treatment with the test item were noted at any dose level. No test item-related histopathology findings were noted neither in males nor in females treated with the test item at the highest dose. No test item-related histopathology findings were noted during examination of reproductive organs of female which did not become pregnant and its male partner at the dose level of 50 mg/kg/day.
Number of pups at first litter check and viability of pups up to day 4 post partum were considered not to be affected by the treatment with the test item at any dose level. Sex ratios at first litter check and on day 4 post partum were considered not to be affected by the treatment with the test item at any dose level. No abnormal findings were noted at first litter check and during the first 4 days post partum at any dose level. Pups body weights and body weight gain to day 4 post partum were not affected by the treatment with the test item at any dose level. No findings were noted at macroscopic examination of pups at any dose level.
Under the conditions described for this study, the general NOAEL (No Observed Adverse EffectLevel) for parental organism was considered to be 1000 mg/kg body weight/day.The NOEL (No Observed Effect Level) for reproduction/developmental toxicity was considered to be 1000 mg/kg body weight/day.
Short description of key information:
In a OECD 421 reporoduction screening test the NOAEL (No Observed Adverse EffectLevel) for parental organism was considered to be 1000 mg/kg body weight/day.The NOEL (No Observed Effect Level) for reproduction/developmental toxicity was consideredto be 1000 mg/kg body weight/day.
Justification for classification or non-classification
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.