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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from RTECS

Data source

Reference
Reference Type:
other: Authoritative database
Title:
RTECS no DE4081000; Acute oral toxicity study for the test chemical 4-Amino-1, 8-naphthalimide
Author:
RTECS - United States trademark owned and licensed under authority of the U.S. Government
Year:
2016
Bibliographic source:
RTECS, Registry of Toxic Effects of Chemical Substances

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Acute oral toxicity study was conducted to determine the oral toxic nature of the test compound 4-Amino-1,8-naphthalimide.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
4-aminonaphthalene-1,8-dicarboximide
EC Number:
217-110-1
EC Name:
4-aminonaphthalene-1,8-dicarboximide
Cas Number:
1742-95-6
Molecular formula:
C12H8N2O2
IUPAC Name:
6-amino-1H-benzo[de]isoquinoline-1,3(2H)-dione
Constituent 2
Reference substance name:
4-Amino-1,8-naphthalimide
IUPAC Name:
4-Amino-1,8-naphthalimide
Test material form:
not specified
Details on test material:
- Name of test material (as cited in study report): 1H-Benz(de)isoquinoline1,3(2H)dione,6-amino-
- Molecular formula (if other than submission substance): C12H8N2O2
- Molecular weight (if other than submission substance): 212.207 g/mol
- Substance type: Organic

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
No data available
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 10 000 mg/kg bw
Based on:
test mat.
Mortality:
No data available
Clinical signs:
other: No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
The acute oral lethal dose (LD50) for the test compound 4-Amino-1, 8-naphthalimide is found to be >10000 mg/kg.
Executive summary:

Acute oral toxicity study was conducted on rats to determine the oral toxic nature of the test compound4-Amino-1, 8-naphthalimide. 50% mortality was not observed at the doses studied and the acute oral lethal dose (LD50) for the test compound4-Amino-1, 8-naphthalimide is found to be >10000 mg/kg.

As per CLP classification, the test material does not classify as an acute oral toxicant.