Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 208-253-0 | CAS number: 518-47-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Adsorption / desorption:
Based on the available studies for the target substance Fluorescein sodium (Cas no.518-47-8) are summarized as fallowed:
From peer reviewed journal (Bull. Environ. Contam. Toxicol. (1998) 61:426-432) study investigated the dissipation and fate of phloxine B and uranine in water and sediment in the spill site. Distribution coefficients (Koc) of phloxine B and uranine were determined.
It was observed that adsorption coefficients of uranine were higher in soil than in sediments although the organic carbon content of the sediment is higher than soil. Uranine was not detected in the sediment samples after 284 days. Uranine was less persistent compared to Phloxine B.
The adsorption coefficient (Koc) value of Uranine in soil was found to be 88.81along with percentage organic carbon of 3.10%.While same test condition for sediment indicate the adsorption coefficient (Koc) value of Uranine as 69.43 along with percentage organic carbon of 3.94%.
While the objective of the other study was to utilize batch studies to determine the adsorptive characteristics of fluorescein with a low organic content alluvial aquifer sand.
Inspection of the adsorption isotherm for fluorescein indicates that it demonstrated linearity at low concentrations with non linearity experienced at higher concentrations. The koc value of 120 cm3/g for fluorescein was obtained in the batch equilibrium studies. The Freundlich adsorption isotherm could not be estimated due to the discontinuous nature of the adsorption isotherm and background fluorescence observed at higher concentrations. (Groundwater, Volume 29, Issue 3, May 1991, Pages 341–349)
Thus overall experimental studies indicate that the test substance Fluorescein sodium (uranine) have tendency to adsorbed higher in soil than in sediments.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.