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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Toxicity to reproduction: other studies

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Administrative data

Endpoint:
toxicity to reproduction: other studies
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: guideline study; not available for review
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Reproductive endpoints in general toxicity studies: are they predictive?
Author:
Chapin RE et al.
Year:
1998
Bibliographic source:
Reproductive Toxicology 12, 489-494
Reference Type:
publication
Title:
Unnamed
Year:
1990

Materials and methods

Principles of method if other than guideline:
Type: other: subchronic
Method: other: determination of sperm motility and concentration in males and length of oestrus cycle and vaginal cytology following repeated dose according EPA OPP 82-1
GLP compliance:
yes
Type of method:
in vivo

Test material

Constituent 1
Chemical structure
Reference substance name:
o-cresol
EC Number:
202-423-8
EC Name:
o-cresol
Cas Number:
95-48-7
Molecular formula:
C7H8O
IUPAC Name:
o-cresol
Details on test material:
IUCLID4 Test substance: other TS: o-cresol purity > 99 %

Test animals

Species:
mouse
Strain:
B6C3F1
Sex:
male/female

Administration / exposure

Route of administration:
oral: feed
Duration of treatment / exposure:
90 d
Frequency of treatment:
daily
Doses / concentrations
Remarks:
Doses / Concentrations:
0, 1250, 5000 ppm
Basis:

Control animals:
yes, concurrent no treatment
Details on study design:
Duration of test: 90

Results and discussion

Any other information on results incl. tables

RS-Freetext:

 

Male:

Reproductive organ weights (R. testicle and R. epididymidis) showed no difference to the respective controls; epididymal tail weight was significantly reduced when compared to the respective control.

Spermatogonial measurements revealed no findings.

 

Female:

Mean estrous cycle length was significantly prolonged at 20000 ppm.

Applicant's summary and conclusion