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Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2000-09-26 - 2001-01-30
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The GLP-study was performed according to an internationally accepted guideline.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2001
Report date:
2001

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
yes
Remarks:
The partition coefficient of YOFCO MAS was estimated using the solubility data in n-octanol (as obtained in the preliminary test) and in water.
GLP compliance:
yes (incl. QA statement)
Type of method:
other: The partition coefficient of YOFCO MAS was estimated using the solubility data in n-octanol (as obtained in the preliminary test) and in water.
Partition coefficient type:
octanol-water

Test material

Constituent 1
Test material form:
other: solid
Details on test material:
Purity: 100%

Study design

Analytical method:
other: UV spectroscopy

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
4.9
Temp.:
20 °C

Any other information on results incl. tables

Initial Weight of

Test Item

n-octanol added

Dilution Factor

Absorbance

Measured Concentration

Solubility in

n-octanol

Mean

(g)

(ml)

 

 

(mg/l)

m

m

1.39

20

1000

0.6840

58.343

58.343

 

1.51

20

1000

0.8274

71.491

71.491

65

Applicant's summary and conclusion

Conclusions:
The partition coefficient, log Pow, of YOFCO MAS was calculated to be 4.9.
Executive summary:

Neither the HPLC-method according to OECD Guideline No. 117 nor the fiask-shaking method according to OECD Guideline No. 107 were applicable for the determination of the partition coefficient of YOFCO MAS. Thus, the log Pow-value for the test item was estimated from its solubility in n-octanol and in water, respectively.

In the present study, the n-octanol solubility of YOFCO MAS at room temperature was determined to be 65 g/l. The water solubility of the test item was determined under RCC study 784778 to be 0.8 mg/l.

Therefore, the partition coefficient, log Pow, of YOFCO MAS was calculated to be 4.9.