[2R-[2α(E),3β]]-2-[2-(3,4-dihydro-6-methoxy-1(2H)-naphthylidene)ethyl]-2-ethyl-3-hydroxycyclopentan-1-one

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Apr 1993

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: According to OECD guidelines

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1993

Report date:

1994

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

Deviations:

no

Principles of method if other than guideline:

Not relevant

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

[2R-[2α(E),3β]]-2-[2-(3,4-dihydro-6-methoxy-1(2H)-naphthylidene)ethyl]-2-ethyl-3-hydroxycyclopentan-1-one

EC Number:

257-409-4

EC Name:

[2R-[2α(E),3β]]-2-[2-(3,4-dihydro-6-methoxy-1(2H)-naphthylidene)ethyl]-2-ethyl-3-hydroxycyclopentan-1-one

Cas Number:

51773-49-0

Molecular formula:

C20H26O3

IUPAC Name:

17 beta-Hydroxy-3-methoxy-18-methyl-8,14-seco-1,3,5(10),9(11)-estratetraen-14-one

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Details on test material:

- Name of test material (as cited in study report): 13-Ethylsecol
- Analytical purity: 97.9%
- Lot/batch No.: 57130532

Sampling and analysis

Analytical monitoring:

no

Test solutions

Vehicle:

no

Test organisms

Test organisms (species):

Daphnia magna

Study design

Test type:

static

Water media type:

freshwater

Total exposure duration:

48 h

Results and discussion

Effect concentrations

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

> 10 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Any other information on results incl. tables

No immobilized Daphnia were observed either in the test solution or in any of the control

groups .

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

The results indicate no acute toxicity of 13-Ethysecol to Daphnia magna at a concentration up to 10 mg/L, which was the maximum solubility of
the test compound under the conditions of the test. The 48-hour EC50 (immobilisation) value is > 10 mg/L.

Executive summary:

The purpose of this study was to determine the acute toxicity (immobilization, EC50/48 hours) of Ethysecol to Daphnia magna. The study was conducted in accordance with OECD Guideline for Testing of Chemicals No. 202.

Forty Daphnia (less than 24 hours old) were used for the test solution, forty for the control, and forty for the solvent control group. The organisms were exposed to a test concentration of 10 mg/L (nominal). The solvent was applied at a concentration of 0.1 mg/L. The test species were exposed for a period of 48 hours.

The immobilization was recorded at 24 hours and 48 hours. No immobilized Daphnia were observed either in the test solution or in any of the control groups. The results indicate no acute toxicity of 13 -Ethysecol to Daphnia magna at a concentration up to

10 mg/L, which was the maximum solubility of the test compound under the conditions of the test. The 48-hour EC50 (immobilisation) value is > 10 mg/L.