Registration Dossier
Registration Dossier
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EC number: 201-058-1 | CAS number: 77-78-1
Carcinogenicity
Administrative data
- Endpoint:
- carcinogenicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Year:
- 1 972
- Bibliographic source:
- IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work), p. V4 274 (1974).
Materials and methods
Test material
- Reference substance name:
- Dimethyl sulphate
- EC Number:
- 201-058-1
- EC Name:
- Dimethyl sulphate
- Cas Number:
- 77-78-1
- Molecular formula:
- C2H6O4S
- IUPAC Name:
- dimethyl sulfate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- other: unspecified oil
- Details on exposure:
- Among 8 BD rats given weekly sc doses of 16 mg/kg bw in oil (total dose, 784 mg/kg bw).
Among 12 BD rats receiving 8 mg/kg bw in oil weekly for 394 days (total dose, 466 mg/kg bw) - Duration of treatment / exposure:
- 394 days
- Frequency of treatment:
- weekly
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
16 mg/kg bw
Basis:
no data
- Remarks:
- Doses / Concentrations:
8 mg/kg bw
Basis:
no data
Results and discussion
Results of examinations
- Details on results:
- Among 8 BD rats given weekly sc doses of 16 mg/kg bw in oil (total dose, 784 mg/kg bw).. 4/6 survivors developed local sarcomas within 236-414 days, 1 with metastases to lung.
Among 12 BD rats receiving 8 mg/kg bw in oil weekly for 394 days (total dose, 466 mg/kg bw).. 7/11 showed local sarcomas, 3 of which had metastasized to lung and regional lymph nodes. Mean tumor induction time was 500 days. One rat liver carcinoma. No control data were reported.
Applicant's summary and conclusion
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