Registration Dossier
Registration Dossier
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EC number: 235-227-6 | CAS number: 12136-45-7
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- other: Published data
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Effect of prolonged individual caging on toxicity parameters in rats.
- Author:
- Wiberg, G.S., Grice, H.C
- Year:
- 1 965
- Bibliographic source:
- Fd. Cosmet. Toxicol. 3:597-603.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- KCl was administrated as a single dose by the intraperitoneal route to groups of 10 rats.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Potassium chloride
- EC Number:
- 231-211-8
- EC Name:
- Potassium chloride
- Cas Number:
- 7447-40-7
- IUPAC Name:
- potassium chloride
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- KCl was administrated as a single dose by the intraperitoneal route to groups of 10 rats.
- Doses:
- 660 mg
- No. of animals per sex per dose:
- 10
- Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 660 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: KCl was administrated as a single dose by the intraperitoneal route to groups of 10 rats.
Applicant's summary and conclusion
- Conclusions:
- The LD50 value of 660 mg/kg was determined in this study by intravenous route of administration
- Executive summary:
The LD50 value of 660 mg/kg was determined in this study by intravenous route of administration
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