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EC number: 235-227-6 | CAS number: 12136-45-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- other: Published data
- Adequacy of study:
- key study
- Study period:
- October 19 - November 2, 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Justification for type of information:
- According to OECD 402 and GLP procedures. Alternatively and more conveniently Potassium oxide is synthesized by heating potassium nitrate with metallic potassium: 2 KNO3 + 10 K → 6 K2O + N2 Therefore, the health effects of potassium nitrate need to be considered in the assessment of Potassium oxide
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- limit dose of 5,000 mg/kg tested
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Potassium nitrate
- EC Number:
- 231-818-8
- EC Name:
- Potassium nitrate
- Cas Number:
- 7757-79-1
- Molecular formula:
- HNO3.K
- IUPAC Name:
- Potassium nitrate
- Details on test material:
- Alternatively and more conveniently Potassium oxide is synthesized by heating potassium nitrate with metallic potassium:2 KNO3 + 10 K → 6 K2O + N2Therefore, the health effects of potassium nitrate need to be considered in the assessment of Potassium oxidewhite granules- Analytical purity: K2O - 44.86%Total Nitrogen - 13.54%- Lot/batch No.: - Expiration date of the lot/batch: July 6, 2001- Stability under test conditions: Test substance is expected to be stable for the duration of testing- Storage condition of test material: room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Received from Ace Animals, Inc., Boyertown, PA on October 10, 2000
- Age at study initiation: Young adult (8-9 weeks)
- Weight at study initiation: males 218-246 grams and females 194-215 grams at experimental start
- Fasting period before study:
- Housing: The animals were singly housed in suspended stainless steel caging with mesh
floors which conform to the size recommendations in the most recent Guide for the
Care and Use of Laboratory Animals DHEW (NIH). Litter paper was placed beneath
the cage and was changed at least three times per week.
- Diet (e.g. ad libitum): Purina Rodent Chow #5012
- Water (e.g. ad libitum): Filtered tap water was supplied ad libitum by an automatic water dispensing
system.
- Acclimation period: 9 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17-21C
- Humidity (%):
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light): 12 hour light/dark cycle
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: moistened with water
- Details on dermal exposure:
- TEST SITE
- Area of exposure: dose area of approximately 2 inches x 3 inches
- % coverage: approximately 10% of the body surface
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes, with water
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): (conc. 85%)Five thousand mg/kg of bodyweight of the
test substance (6.25 g/kg of test mixture)
- Constant volume or concentration used: yes
- For solids, paste formed: yes - Duration of exposure:
- 24 hours
- Doses:
- (conc. 85%) Five thousand mg/kg of bodyweight of the test substance (6.25 g/kg of test mixture)
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days (or other?) 14 days
- Frequency of observations and weighing:
- Necropsy of survivors performed: yes/no Yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other:
The animals were observed for mortality, signs of gross toxicity, and behavioral changes at 1 and 5
hours after application and at least once daily thereafter for 14 days. Observations included gross
evaluation of skin and fur, eyes and mucous membranes, respiratory, circulatory, autonomic and central
nervous systems, somatomotor activity and behavior pattern. Particular attention was directed to
observation of tremors, convulsions, salivation, diarrhea and coma.
Gross necropsies were performed on all animals. Tissues and organs of the thoracic and abdominal cavities were examined.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- all animals survived
- Clinical signs:
- other: all animals appeared active and healthy
- Gross pathology:
- Gross pathology: All animals survived, gained weight and appeared active and healthy. There were no signs of gross toxicity, adverse pharmacologic effects or abnormal behavior. No gross abnormalities were noted for the animals necropsied at the conclusion of the 14-day observation period.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Acute Dermal Toxicity: An LD50 value of >5000 mg/kg was obtained. The dermal LD50 in male and female rats is >5000 mg/kg.
Alternatively and more conveniently Potassium oxide is synthesized by heating potassium nitrate with metallic potassium:
2 KNO3 + 10 K → 6 K2O + N2
Therefore, the health effects of potassium nitrate need to be considered in the assessment of Potassium oxide
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