Registration Dossier
Registration Dossier
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EC number: 500-086-4 | CAS number: 35238-34-7
Bioaccumulation: aquatic / sediment
Administrative data
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to established testing guidelines without GLP compliance. Furthermore, study detail is lacking.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: MITI - Japan
- Deviations:
- not specified
- Principles of method if other than guideline:
- Flow-through exposure
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4,4'-isopropylidenediphenol
- EC Number:
- 201-245-8
- EC Name:
- 4,4'-isopropylidenediphenol
- Cas Number:
- 80-05-7
- Molecular formula:
- C15H16O2
- IUPAC Name:
- 2,2-bis(4-hydroxyphenyl)propane
- Reference substance name:
- 4,4’-isopropylidenediphenol
- IUPAC Name:
- 4,4’-isopropylidenediphenol
- Reference substance name:
- Phenol, 4,4’-(1-methylethylidene)bis-
- IUPAC Name:
- Phenol, 4,4’-(1-methylethylidene)bis-
- Reference substance name:
- Bisphenol A
- IUPAC Name:
- Bisphenol A
- Details on test material:
- As per IUCLID5 Sections 1.1. -1.4. for Bisphenol A.
Constituent 1
Constituent 2
Constituent 3
Constituent 4
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
As per IUCLID5 Sections 1.1. -1.4. for Bisphenol A. - Radiolabelling:
- not specified
Sampling and analysis
- Details on sampling:
- No data
Test solutions
- Details on preparation of test solutions, spiked fish food or sediment:
- A dispersant (HCO-40) was used to prepare the test substance dosing solutions.
Test organisms
- Test organisms (species):
- Oryzias latipes
- Details on test organisms:
- No data
Study design
- Route of exposure:
- aqueous
- Test type:
- flow-through
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 8 wk
Test conditions
- Hardness:
- No data
- Test temperature:
- No data
- pH:
- No data
- Dissolved oxygen:
- No data
- TOC:
- No data
- Salinity:
- No data - fresh water
- Details on test conditions:
- No data
- Nominal and measured concentrations:
- 15 µg/l (15.0 - 15.5 µg/l) and 150 µg/l (145.9 - 155.7 µg/l)
- Reference substance (positive control):
- not specified
- Details on estimation of bioconcentration:
- No data
Results and discussion
Lipid content
- Remarks on result:
- other: No data
Bioaccumulation factoropen allclose all
- Type:
- BCF
- Value:
- ca. 20 - ca. 68
- Basis:
- whole body w.w.
- Calculation basis:
- steady state
- Remarks on result:
- other: Conc.in environment / dose:15 mg/L
- Type:
- BCF
- Value:
- ca. 5 - ca. 13.3
- Basis:
- whole body w.w.
- Calculation basis:
- steady state
- Remarks on result:
- other: Conc.in environment / dose:150 mg/L
Depuration
- Elimination:
- not specified
- Details on kinetic parameters:
- No data
- Metabolites:
- No data
- Results with reference substance (positive control):
- No data
- Details on results:
- No data
- Reported statistics:
- No data
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The bioconcentration Factor (BCF) for Bisphenol A ranged approximately 5 to 68-fold for concentrations of 15 to 150 mg/L. BCF was only 5 - 13.3 at 150 mg/L suggesting a potential to plateau at higher Bisphenol A concentrations. These findings suggest the potential for Bisphenol A to bioconcentrate in aquatic organisms is low to moderate and may be concentration limited. Therefore, it is expected that 2-Acetone polymer with phenol (BPA-Tars) will have similar bioconcentration potential.
- Executive summary:
Bisphenol A, a structural analog of 2 -Acetone polymer with phenol (BPA-Tars) was evaluated for bioconcentration potential in Oryzias latipes (orange-red killfish) using a MITI test guideline and flow-through exposure for an eight-week period. The bioconcentration Factor (BCF) for Bisphenol A ranged approximately 5 to 68-fold for concentrations of 15 to 150 mg/L. BCF was only 5 - 13.3 at 150 mg/L suggesting a potential to plateau at higher Bisphenol A concentrations. These findings suggest the potential for Bisphenol A to bioconcentrate in aquatic organisms is low to moderate and may be concentration limited. Therefore, it is expected that 2-Acetone polymer with phenol (BPA-Tars) will have similar bioconcentration potential.
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