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EC number: 205-585-8 | CAS number: 143-13-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 16 August - 22 September 2000
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP study conducted according to OECD Guideline 471 with deviations: read-across substance
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- yes
- Remarks:
- read-across substance
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes (incl. QA statement)
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Decyl acetate
- EC Number:
- 203-942-2
- EC Name:
- Decyl acetate
- Cas Number:
- 112-17-4
- IUPAC Name:
- decyl acetate
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): DECYLACETATE
- Source: Haarmann & Reimer GmbH
- Physical state: Colorless to pale yellowish liquid
- Analytical purity: 99.1%
- Lot/batch No.: 29120015
- Date of receipt: 24 March 2000
- Storage condition of test material: Cool and dry
Constituent 1
Method
- Target gene:
- None
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and TA 102
- Details on mammalian cell type (if applicable):
- Not applicable
- Additional strain / cell type characteristics:
- other: see table 7.6.1/1
- Metabolic activation:
- with and without
- Metabolic activation system:
- 10 % S9-fraction; S9 fraction prepared from liver homogenates of male Sprague-Dawley rats induced with Aroclor 1254 (500 mg/kg bw)
- Test concentrations with justification for top dose:
- Experiment 1 (Plate incorporation method):
- Without S9: 15, 50, 150, 500, 1500 and 5000 µg/plate in strains TA98, TA1535 and TA1537
- Without S9: 5, 15, 50, 150, 500 and 1500 µg/plate in strains TA100 and TA102
- With S9: 5, 15, 50, 150, 500 and 1500 µg/plate in strains TA1535, TA1537, TA98, TA100 and TA102
Experiment 2 (Plate incorporation method):
- Without S9: 5, 15, 50, 150 and 500 µg/plate in strains TA100 and TA1537
- Without S9: 50, 150, 500, 1500 and 5000 µg/plate in strain TA1535
- Without S9: 15, 50, 150, 500, 1500 and 5000 µg/plate in strain TA98
- Without S9: 1.5, 5, 15, 50, 150 and 500 µg/plate in strain TA102
- With S9: 1.5, 5, 15, 50, 150 and 500 µg/plate in strain TA100
- With S9: 15, 50, 150, 500 and 1500 µg/plate in strain TA1535
- With S9: 5, 15, 50, 150, 500 and 1500 µg/plate in strains TA98 and TA102
- With S9: 5, 15, 50, 150 and 500 µg/plate in strains TA1537 - Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: Ethanol
Controlsopen allclose all
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- Remarks:
- Ethanol
- True negative controls:
- not specified
- Positive controls:
- yes
- Positive control substance:
- other: sodium azide: 0.7 µg/plate for TA100 and TA1535; 2-nitrofluorene: 2.5 µg/plate for TA98; 9-aminoacridine: 50 µg/plate for TA1537; Mitomycin C: 0.15 µg/plate for TA102
- Remarks:
- without S9
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- Remarks:
- Ethanol
- True negative controls:
- not specified
- Positive controls:
- yes
- Positive control substance:
- other: 2-aminoanthracene: 0.7 µg/plate for TA98; 0.8 µg/plate for TA100; 1.2 µg/plate for TA1535; 1.5 µg/plate for TA1537; 1.7 µg/plate for TA102
- Remarks:
- with S9
- Details on test system and experimental conditions:
- SOURCE OF TEST SYSTEM: - All Salmonella typhimurium strains received from Dr. Bruce N. Ames, University of California, Berkeley, California, U.S.A.
METHOD OF APPLICATION: In agar (plate incorporation)
DURATION
- Incubation period: Plates were incubated in the dark at 37 °C for 48-72 h
NUMBER OF REPLICATIONS:
- 3 plates/dose for treatment, negative, vehicle and positive controls
DETERMINATION OF CYTOTOXICITY
- Method: To determine the toxicity of test item, plates were examined for the existence of a normal background lawn.
OTHER:
- The genotypes of the tester strains (histidine requirement, spontaneous reversion frequency, sensitivity to UV-light, crystal violet and ampicillin) were checked in each experiment.
- The Vogel-Bonner minimal plates, the test compound, and the S9-mix were checked for sterility. - Evaluation criteria:
- No data
- Statistics:
- Estimation of the statistical significance of the difference between the mean number of revertants in the negative controls and the plates at each dosage level, using a X2-test (Mohn and Ellenberger, 1977).
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and TA 102
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Additional information on results:
- TEST-SPECIFIC CONFOUNDING FACTORS
- Precipitation: Precipitation of the test compound on the plates was not observed.
COMPARISON WITH HISTORICAL CONTROL DATA: Results were compared with historical control data of the laboratory (1998-2000)
ADDITIONAL INFORMATION ON CYTOTOXICITY:
- In the absence of S9-mix, test item was bacteriotoxic towards the strains TA100 and TA102 at 500 μg/plate, towards strain TA1537 at 1500 μg/plate, and towards strain TA98 at 5000 μg/plate. In the presence of S9-mix test item was bacteriotoxic towards the strains TA1537 and TA102 at 500 μg/plate and towards the strains TA1535, TA98, and TA100 at 1500 μg/plate. - Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
Full results can be found in the attached study report.
Read-across justification for the use of decyl acetate can also be found in the attached justification report.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative with metabolic activation
negative without metabolic activation
Under the test conditions, DECYLACETATE is not considered as mutagenic in S. typhimurium (TA1535, TA1537, TA98, TA100 and TA102) strains. - Executive summary:
In a reverse gene mutation assay in bacteria, performed according to the OECD Guideline 471 and in compliance with GLP, strains of Salmonella typhimurium (TA1535, TA1537, TA98, TA100 and TA102) were exposed to DECYLACETATE at the following concentrations:
Experiment 1 (Plate incorporation method):
- Without S9: 15, 50, 150, 500, 1500 and 5000 µg/plate in strains TA98, TA1535 and TA1537
- Without S9: 5, 15, 50, 150, 500 and 1500 µg/plate in strains TA100 and TA102
- With S9: 5, 15, 50, 150, 500 and 1500 µg/plate in strains TA1535, TA1537, TA98, TA100 and TA102
Experiment 2 (Plate incorporation method):
- Without S9: 5, 15, 50, 150 and 500 µg/plate in strains TA100 and TA1537
- Without S9: 50, 150, 500, 1500 and 5000 µg/plate in strain TA1535
- Without S9: 15, 50, 150, 500, 1500 and 5000 µg/plate in strain TA98
- Without S9: 1.5, 5, 15, 50, 150 and 500 µg/plate in strain TA102
- With S9: 1.5, 5, 15, 50, 150 and 500 µg/plate in strain TA100
- With S9: 15, 50, 150, 500 and 1500 µg/plate in strain TA1535
- With S9: 5, 15, 50, 150, 500 and 1500 µg/plate in strains TA98 and TA102
- With S9: 5, 15, 50, 150 and 500 µg/plate in strains TA1537
Metabolic activation system used in this test 10 % S9; S9 fraction prepared from liver homogenates of male Sprague-Dawley rats induced with Aroclor 1254 (500 mg/kg bw). Negative, vehicle and positive control groups were also included in mutagenicity tests.
In the absence of S9-mix, test item was bacteriotoxic towards the strains TA100 and TA102 at 500 μg/plate, towards strain TA1537 at 1500 μg/plate, and towards strain TA98 at 5000 μg/plate. In the presence of S9-mix test item was bacteriotoxic towards the strains TA1537 and TA102 at 500 μg/plate and towards the strains TA1535, TA98, and TA100 at 1500 μg/plate. Precipitation of the test compound on the plates was not observed. The test item did not induce a significant or dose related increase in the mutation frequency of the tester strains in the absence and presence of a metabolic activation system. The positive and negative/vehicle controls induced the appropriate responses in the corresponding strains indicating the validity of the study.
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