Registration Dossier
Registration Dossier
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EC number: 244-499-5 | CAS number: 21651-19-4
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only LD50 and information on food reduction provided.
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Oral Toxicity and Repellency of 933 Chemicals to House and Deer Mice
- Author:
- Schafer EW and Bowles, Jr WA
- Year:
- 1 985
- Bibliographic source:
- Arch. Environ. Contam. Toxicol, Vol 14, pp 111 -129
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Tin monoxide
- EC Number:
- 244-499-5
- EC Name:
- Tin monoxide
- Cas Number:
- 21651-19-4
- Molecular formula:
- O Sn
- IUPAC Name:
- Tin(II) oxide
- Details on test material:
- none provided other than identifier
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: deer
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Test institue probably U.S. Department or Interior - Fish and Wildlife Service, Denver Wildlife Research Center, Denver Federal Center, Denver, Colorado 80225
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- other: applied via wheat (2% w/w)
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 3 days
- Frequency of treatment:
- daily
- No. of animals per sex per dose:
- not clear from publication, could be 2 or 5
- Details on study design:
- 4 day observation period
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Mortality:
- mortality observed, treatment-related
- Body weight and weight changes:
- effects observed, treatment-related
- Food consumption and compound intake (if feeding study):
- effects observed, treatment-related
Effect levels
- Dose descriptor:
- other: LD50
- Effect level:
- ca. 775 mg/kg bw/day (nominal)
- Based on:
- not specified
- Sex:
- not specified
- Basis for effect level:
- other: All mice refused to eat the wheat treated with SnO.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
