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Short-term toxicity to aquatic invertebrates

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Description of key information

QSAR model, iSafeRat holistic approach v1.4, key study, validity 2:
48h-EC50 = 9.0 mg/L (95% CL: 8.2 - 9.9 mg/L).

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
9 mg/L

Additional information

To assess the toxicity of the registered substance to aquatic invertebrates, one data point is available.

This value (KREATiS, 2015), assessed as a key datapoint, is a QSAR. This QSAR prediction (iSafeRat holistic approach v1.4) was performed on the registered substance, to assess the acute toxicity of the substance to daphnids. This QSAR has been validated to be compliant with the OECD recommendations for QSAR modelling (OECD, 2004) and predicts the endpoint value which would be expected when testing the substance under experimental conditions in a laboratory following OECD Guideline 202. The immobility of the daphnids was determined using a validated QSAR for the Mode of Action in question, (MOA 1, non-polar narcosis). Use of this MOA for substituted α,β-unsaturated ketones has previously been demonstrated as acceptable in a position paper (KREATiS, 2015; available in the Endpoint Study Record). This QSAR is based on validated data for a training set of 58 chemicals derived from 48-hour tests on daphnids, for which the concentrations of the test substance had been determined by chemical analyses over the test period. The water solubility of the substance given as input was derived from the experimental log Kow value, measured at 3.40 with a slow-stirring method. The substance falls within the applicability domain of the model. The 48h-EC50 based on mobility was determined to be 9.0 mg/L (95% CL: 8.2 - 9.9 mg/L).