3-phenylpropan-1-ol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

1971

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Remarks:

old report but sufficient for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1971

Report date:

1971

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

not specified

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

3-phenylpropan-1-ol

EC Number:

204-587-6

EC Name:

3-phenylpropan-1-ol

Cas Number:

122-97-4

Molecular formula:

C9H12O

IUPAC Name:

3-phenylpropan-1-ol

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 150 - 300 g

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

corn oil

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 50 %

Doses:

1470, 2150, 3160 and 4640 mg/kg bw

No. of animals per sex per dose:

10 animals in the 5000 mg/kg group and 5 animals in each of the other groups were used.

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Other examinations performed: clinical signs

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

2 250 mg/kg bw

Based on:

test mat.

95% CL:

> 1 680 - < 3 000

Mortality:

In the 5000 mg/kg bw dose group, 9/10 animals died. Mortality occured in all dose groups.

Clinical signs:

other: Clinical signs observed were depression, hypopnea, ataxia and piloerection.

Gross pathology:

Some of the dead rats and of those that were sacrifieced at termination had dark red areas in the lungs.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

In an acute oral toxicity study in rats, the LD50 was found to be 2250 mg/kg bw.

Executive summary:

An acute oral toxicity study was conducted on rats. First, a dose of 5000 mg/kg bw was tested and 9/10 animals died. Afterwards the following doses were applied: 1470, 2150, 3160 and 4640 mg/kg bw. Depression, hypopnea, ataxia and piloerection were observed and some of the dead animals or those who were sacrificed after study termination had dark red areas in the lungs. Mortality occured in all dose groups. Based on the available results, the LD50 was determined to be 2250 mg/kg bw.