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In accordance with column 2 of REACH annexes VII and VIII, acute, aquatic toxicity studies do not need to be conducted if there are mitigating factors indicating that aquatic toxicity is unlikely to occur, for instance, if the substance is highly insoluble in water or the substance is unlikely to cross biological membranes. As the substance is both highly insoluble in water (WS <8 ug/l) and has a high molecular weight and size making availability very unlikely, aquatic toxicity is unlikely and the acute, aquatic toxicity endpoints are waived. Additionally, as the use is in fuels, resulting in combustion, no relevant exposure of the aquatic compartment is expected.

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