Registration Dossier
Registration Dossier
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EC number: 200-254-4 | CAS number: 56-06-4
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Based on the negative logPow value, the low molecular weight and the presence of the OH-group for phase-II metabolism, the substance is judged to have no potential for bioaccumulation.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
DAHP is used in research mostly in cell culture studies or by intraperitoneal injection; it has not been developed as a drug. The doses used in research are fairly high, e.g. 5 - 10 mM in cell culture and 0.5 – 1 g/kg bw for intraperitoneal injection. DAHP is a
selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo tetrahydrobiopterin synthesis.
The absence of significant toxicity even at high doses in the oral toxicity studies indicate efficient first pass metabolism.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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