Registration Dossier
Registration Dossier
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EC number: 201-072-8 | CAS number: 77-95-2
Endpoint summary
Administrative data
Description of key information
The read across substances salicylic acid as well as chlorogenic acid are not skin sensitizing.
Additional information
Sensitisation data:
In a human maximization test the read across substance salicylic acid was tested as a potential skin sensitizer. 25 healthy adult subjects (18 -50 years) were tested. A concentration of salicylic acid of 20 % and 10 % were applied respectively during the induction phase and the challenge test. None of the tested subjects showed sensitization after salicylic acid exposure. Thus, in the human maximization test, salicylic acid is not sensitizing to skin.
In a clinical skin-scratch test the read across substance chlorogenic acid was tested as a potential skin sensitizer. 200 French patients were tested, using a concentration of 1 % chlorogenic acid solution. None of the tested patients showed sensitization after chlorogenic acid exposure.
From these results of the read across substances salicylic acid and chlorogenic acid we can assume, that quinic acid is not skin sensitizing, too.
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