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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study is not done according to OECD guideline. But it is a well documented study.

Data source

Reference
Reference Type:
publication
Title:
Untersuchungen über Thromboseprophylaxe mit organischen Salzen seltener Erden.
Author:
Vincke, E. and Never, H. E.
Year:
1944
Bibliographic source:
Zeitschrift fuer die Gesamte Experimentelle Medizin. 113:536

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
White mice (15 - 20 g each) were used as test animals. The route of administration was subcutaneous. The solution of the tested substance (concentration between 1 and 10 %) was applied under the dorsal skin of the mice and the duration of observation accounted for up to 6 days after injection.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline
Details on test material:
- Name of test material (as cited in study report): quinic acid
- Other: The solution of quinic acid was neutralized with sodium hydroxide before application.

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
White mice were used as test animals.
- Weight at study initiation: average weight between 15 g and 20 g

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
not specified
Details on exposure:
The solution of the tested substance was applied under the dorsal skin of the mouse.
Doses:
Solutions with concentrations between 1 and 10% of the tested substance were applied.
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
White mice (15 - 20 g each) were used as test animals. The route of administration was subcutaneous. The solution of the tested substance (concentration between 1 and 10 %) was applied under the dorsal skin of the mice and the duration of observation accounted for up to 6 days after injection. Clinical signs were briefly documented.

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
10 other: g/kg bw
Based on:
test mat.
Mortality:
Mortality occurred under strong presyncope and exhaustion.
Clinical signs:
Strong presyncope and exhaustion leading to death were observed. The mice showed no signs of seizures.

Applicant's summary and conclusion

Conclusions:
The tested sodium salt of the quinic acid was tested for subcutaneous toxicity to mice. The subcutaneous toxicity is 10 g/kg bw.
Executive summary:

Neutralized quinic acid was tested for subcutaneous toxicity in mice. The sodium salt of the quinic acid showed a subcutaneous toxicity of 10 g/kg bw. From this result it can be concluded, that the subcutaneous toxicity of quinic acid is relatively low.