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EC number: 943-043-9
CAS number: 8015-91-6
The genotoxicity of the test substance Cinnamon bark oil was tested in
bacterial strains TA1535, TA1537, TA98 and TA100 and E.coli WP2uvrA
according to OECD guideline 471 (Ames test). Two
experiments (using the plate incorporation methodology and
pre-incubation methodology) were performed with concentrations of the
test substance ranging from 1.5 to 5000 µg/plate, with and without
metabolic activation. Negative, vehicle and positive controls were
included as well. The frequency of revertant colonies was recorded.
The negative and positive controls were determined to be valid. All the
positive control chemicals used in the test induced marked increases in
the frequency of revertant colonies, confirming the activity of the
S9-mix and the sensitivity of the bacterial strains. Cytoxicity was
observed in both experiments by a reduction in growth of the bacterial
background lawns, being more apparent in experiment 2 (using
pre-incubation methodology). No significant increases in the frequency
of revertant colonies were recorded for any of the bacterial strains,
with any dose test item, either with or without metabolic activation or
Based on these results the test item Cinnamon bark oil can be considered
non-mutagenic in accordance with the criteria outlined in Annex I of CLP
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