Pentanedioic acid, 2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-, (2S)-

Vapour pressure

Administrative data

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

02 June 2015-18 August 2015

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

GLP-compliant study in accordance with EC A.4 and OECD 104.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2015

Report date:

2015

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Version / remarks:

(2009)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

(2006)

Deviations:

no

Test guideline 3

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7950 (Vapor Pressure)

Version / remarks:

(1996)

Deviations:

no

GLP compliance:

yes

Type of method:

other: Effusion method: isothermal thermogravimetry

Test material

Test material information

Constituent 1

Reference substance name:

(2S)-2-(1,3-DIOXO-2,3-DIHYDRO-1H-ISOINDOL-2-YL)PENTANEDIOIC ACID

EC Number:

608-945-6

Cas Number:

340-90-9

Molecular formula:

C13H11NO6

IUPAC Name:

(2S)-2-(1,3-DIOXO-2,3-DIHYDRO-1H-ISOINDOL-2-YL)PENTANEDIOIC ACID

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Details on test material:

- Name (as cited in study report): Phthalyl-L-Glu
- Appearance: white powder
- Storage conditions: room temperature

Results and discussion

Vapour pressure

Vapour pressure 1

Key result

Temp.:

20 °C

Vapour pressure:

< 1.5 other: E-03 Pa

Vapour pressure 2

Key result

Temp.:

25 °C

Vapour pressure:

< 7 other: E-03 Pa

Vapour pressure 3

Temp.:

20 °C

Vapour pressure:

< 1.1 other: E-05 mm Hg

Vapour pressure 4

Temp.:

25 °C

Vapour pressure:

< 5.3 other: E-05 mm Hg

Any other information on results incl. tables

The weight losses of the test substance at 110°C, 120°C, 130°C and 140°C were lower than the weight losses of hexachlorobenzene at the same temperatures. From this it was concluded that vapour pressure of the substance at 20/25°C is lower than the vapour pressure of hexachlorobenzene at 20/25°C (see the table above).

Applicant's summary and conclusion

Conclusions:

In a GLP-compliant study in accordance with EC A.4, OECD 104 and EPA OPPTS 830.7950 using the isothermal thermogravimetric effusion method, the vapour pressure of the substance at 25°C has been determined as < 7.0E-03 Pa. The vapour pressure of the substance at 20°C has been determined as < 1.5E-03 Pa.