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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 941-489-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Study period:
- 2014
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable with restrictions because it is an acceptable and reliable study carried out by OECD ToolBox 3.2.0. Meets generally accepted scientific principles, acceptable for assessment.
Data source
Reference
- Reference Type:
- other: software
- Title:
- QSAR ToolBox 3.2.0.103
- Author:
- OECD
- Year:
- 2 014
- Bibliographic source:
- http://www.oecd.org/env/ehs/risk-assessment/theoecdqsartoolbox.htm
Materials and methods
- Principles of method if other than guideline:
- Read-across from category members
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Difluprednate
- EC Number:
- 245-815-4
- EC Name:
- Difluprednate
- Cas Number:
- 23674-86-4
- IUPAC Name:
- 21-acetoxy-6,9-difluoro-11-hydroxy-3,20-dioxopregna-1,4-dien-17-yl butyrate
- Reference substance name:
- Paramethasone 21-acetate
- EC Number:
- 216-486-4
- EC Name:
- Paramethasone 21-acetate
- Cas Number:
- 1597-82-6
- IUPAC Name:
- 6-fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl acetate
- Reference substance name:
- Fluocinonide
- EC Number:
- 206-597-6
- EC Name:
- Fluocinonide
- Cas Number:
- 356-12-7
- IUPAC Name:
- 2-(4b,12-difluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl)-2-oxoethyl acetate
- Reference substance name:
- Diflorasone di(acetate)
- EC Number:
- 251-575-1
- EC Name:
- Diflorasone di(acetate)
- Cas Number:
- 33564-31-7
- IUPAC Name:
- 6,9-difluoro-21-hydroxy-16-methyl-3,20-dioxopregna-1,4-diene-11,17-diyl diacetate
- Reference substance name:
- 2-bromo-6β,9-difluoro-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-di(acetate)
- EC Number:
- 260-951-4
- EC Name:
- 2-bromo-6β,9-difluoro-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-di(acetate)
- Cas Number:
- 57781-14-3
- IUPAC Name:
- 2-bromo-6,9-difluoro-11-hydroxy-3,20-dioxopregna-1,4-diene-17,21-diyl diacetate
- Reference substance name:
- Flumetasone 21-pivalate
- EC Number:
- 217-901-1
- EC Name:
- Flumetasone 21-pivalate
- Cas Number:
- 2002-29-1
- IUPAC Name:
- 6,9-difluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl pivalate
- Reference substance name:
- Amcinonide
- EC Number:
- 256-915-2
- EC Name:
- Amcinonide
- Cas Number:
- 51022-69-6
- IUPAC Name:
- 2-(4b'-fluoro-5'-hydroxy-4a',6a'-dimethyl-2'-oxo-2',4a',4b',5',6',6a',9a',10',10a',10b',11',12'-dodecahydro-6b'H-spiro[cyclopentane-1,8'-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol]-6b'-yl)-2-oxoethyl acetate
- Reference substance name:
- 14899-36-6
- Cas Number:
- 14899-36-6
- IUPAC Name:
- 14899-36-6
- Reference substance name:
- Deflazacort
- EC Number:
- 238-483-7
- EC Name:
- Deflazacort
- Cas Number:
- 14484-47-0
- IUPAC Name:
- 2-(5-hydroxy-4a,6a,8-trimethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]oxazol-6b-yl)-2-oxoethyl acetate
- Reference substance name:
- Hydrocortisone 21-acetate
- EC Number:
- 200-004-4
- EC Name:
- Hydrocortisone 21-acetate
- Cas Number:
- 50-03-3
- IUPAC Name:
- 11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl acetate
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Constituent 5
Constituent 6
Constituent 7
Constituent 8
Constituent 9
Constituent 10
Test animals
- Species:
- mouse
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 690 mg/kg bw
Any other information on results incl. tables
Toxicity of the target chemical (2.69E+03 mg/kg) is predicted from category members using read-across
based on 10 values within the range 510 - 6.00E+03 mg/kg from 10 nearest neighbours compared by prediction descriptors. Category members are single chemicals or mixtures and are selected based on the profile of the target chemical. Only chemicals having experimental data are listed in the category.
The target chemical FALLS within applicability domain of the prediction.
The descriptor values for the target chemical and the category members in case they are set of
tautomers, set of metabolites or mixtures are calculated using the following rule(s):
1. "logP Multicase" - taking the weighted average value
2. "Molecular weight" - taking the weighted average value
3. "Similarity" - taking the weighted average value
The endpoint data used in the prediction is selected from the following database(s):
1. Complete database_Exp_LD50_Oral_Mouse
The prediction is based on 10 values within the range 1.92 - 2.97, log(1/mol/kg)
Prediction confidence = ± 0.246, log(1/mol/kg) (95.0%)
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Not acute toxicant by oral route.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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