Registration Dossier
Registration Dossier
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EC number: 259-571-1 | CAS number: 55290-62-5
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The 96-h LC50 value is >0.80 µg/L (loading rate) in fish (D. rerio).
Key value for chemical safety assessment
Additional information
The short-term toxicity to freshwater fish was determined in a study according to OECD guideline No 203 and in compliance with GLP criteria (Dr. Noack-Laboratories, 2015).
The test was performed as limit test using the saturated solution of the substance as single concentration. Groups of 7 zebrafish (D. rerio) were exposed to nominal test concentrations of 0 (control) and 0.80 µg/L for 96 hours under flow-through conditions. Test concentrations were analytically verified via LC-MS/MS on study days -1, 0 and daily thereafter until the end of exposure. Measured concentrations were in the range of 0.107 to 0.182 μg/L throughout the exposure with an arithmetic mean measured concentration of 0.145 μg/L. Observations for mortalities and symptoms of toxicity were made at 2, 24, 48, 72 and 96 hours after the start of exposure. Throughout the test no mortality or symptoms of toxicity were observed. Based on these findings the 96 -h LC50 value was determined at >0.145 µg/L i.e. higher than the solubility limit of the test substance in water.
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