Registration Dossier
Registration Dossier
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EC number: 456-350-3 | CAS number: 878665-13-5
Endpoint summary
Administrative data
Description of key information
To assess the bioaccumulation potential of the registered substance, one experimental study was performed according to OECD Guideline 305 with GLP compliance. This study was carried out for a Japanese notification on the registered substance. Bioconcentration factors were less than 38 fold. Therefore, according to this result, the registered substance is not considered as bioaccumulable.
Strong and consistent evidence of mineralisation of the registered substance to the main degradation product, Delta-Damascone mercapto acetic acid (DD-ma), was provided in the biodegradation studies. As for other carboxylic acids, DD-ma readily dissociates into a carboxylate anion and a positively charged hydrogen ion (proton). The dissociation constant of DD mercapto alcanoic acids can be estimated to be between 3 and 4. This estimation is based on a read-across with 2 -mercapto acetic acid, having at 25°C a dissociation constant for pKa of 3.6 (source: Kirk-Othmer Encyclopedia of Chemical Technology. John Wiley & Sons, Inc). Even in the undissociated form, DD-ma is a quite polar compound (log Kow = 3.1 [arithmetical mean value of QSAR results]) and therefore, even if further degradation of this substance has not been demonstrated in these experiments, the final degradation product, DD-ma, is not expected to bioaccumulate significantly in the environment.
Additional information
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