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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to terrestrial arthropods

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Administrative data

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Endpoint:
toxicity to bees: acute contact
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Justification for type of information:
For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.
Reason / purpose for cross-reference:
read-across source
Key result
Duration:
48 h
Dose descriptor:
LD50
Effect conc.:
> 100.4 µg per animal
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Validity criteria fulfilled:
yes
Conclusions:
The contact LD50 value of SY-83 (L-(+)-lactic acid) in the honey bee was determined to be greater than 100.4 µg/bee, the highest concentration tested.
Executive summary:

Mortality rates in all five treatment groups were similar to those observed in the control and solvent control groups. Mortalities did not appear to be treatment related. In conclusion, SY-83 was classified as relatively non-toxic to honey bees. The 48 hour contact LD50 value for SY-83 to honey bees was greater than 100.4 µg/bee, the highest dosage tested.

This information is used in a read-across approach in the assessment of the target substance. For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.

Endpoint:
toxicity to terrestrial arthropods: long-term
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:

Description of key information

The study does not need to be conducted because direct and indirect exposure of the soil compartment is unlikely, see column 2 of REACH Annex IX, point 9.4.

Moreover, DD-lactide is rapidly hydrolysed to lactic acid. Lactic acid is therefore the only relevant species in the environment. Lactic acid is practically non-toxic to aquatic organisms. Corrected for the pH effect, no hazard was identified for lactic acid/lactate. This can be safely extrapolated to the terrestrial compartment. Therefore, based on the chemical safety assessment according to Annex I, testing of short-term or long-term toxicity to soil organisms is not required.

In a supporting study, an acute contact toxicity study in bees, the contact LD50 value of lactic acid in the honeybee was determined to be greater than 100.4 µg/bee, the highest concentration tested.

Key value for chemical safety assessment

Additional information