1,4-Dioxane-2,5-dione, 3,6-dimethyl-, (3R,6R)-

Toxicity to terrestrial arthropods

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

toxicity to bees: acute contact

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Justification for type of information:

For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.

Reason / purpose for cross-reference:

read-across source

Key result

Duration:

48 h

Dose descriptor:

LD50

Effect conc.:

> 100.4 µg per animal

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality

Validity criteria fulfilled:

yes

Conclusions:

The contact LD50 value of SY-83 (L-(+)-lactic acid) in the honey bee was determined to be greater than 100.4 µg/bee, the highest concentration tested.

Executive summary:

Mortality rates in all five treatment groups were similar to those observed in the control and solvent control groups. Mortalities did not appear to be treatment related. In conclusion, SY-83 was classified as relatively non-toxic to honey bees. The 48 hour contact LD50 value for SY-83 to honey bees was greater than 100.4 µg/bee, the highest dosage tested.

This information is used in a read-across approach in the assessment of the target substance. For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.

Reference 2

Endpoint:

toxicity to terrestrial arthropods: long-term

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Description of key information

The study does not need to be conducted because direct and indirect exposure of the soil compartment is unlikely, see column 2 of REACH Annex IX, point 9.4.

Moreover, DD-lactide is rapidly hydrolysed to lactic acid. Lactic acid is therefore the only relevant species in the environment. Lactic acid is practically non-toxic to aquatic organisms. Corrected for the pH effect, no hazard was identified for lactic acid/lactate. This can be safely extrapolated to the terrestrial compartment. Therefore, based on the chemical safety assessment according to Annex I, testing of short-term or long-term toxicity to soil organisms is not required.

In a supporting study, an acute contact toxicity study in bees, the contact LD50 value of lactic acid in the honeybee was determined to be greater than 100.4 µg/bee, the highest concentration tested.