Registration Dossier
Registration Dossier
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EC number: 253-425-0 | CAS number: 37247-91-9
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
There is no indication for genotoxic/mutagenic effects of either burnt dolomitic lime or other calcium or magnesium salts in the available in vitro studies. Furthermore, supportive information is available from comet assays on Ca(OH)2-containing endodontic materials, provided in section 7.12 of the technical dossier (Ribeiro, 2004; Ribeiro, 2005; da Silva, 2007): The results were invariably negative with respect to DNA breakage. This is applicable to calcium contained in burnt dolomitic lime by read-across
Finally, calcium and magnesium are essential mineral nutrients omnipresent in the human body, with daily dietary requirements for adults of approximately 1000 mg (calcium) and 220-260 mg (magnesium), varying by developmental status and age.
Short description of key information:
Calcium magnesium oxide is not genotoxic.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
In view of the omnipresence and essentiality of Ca and Mg, and of the physiological non-relevance of any pH shift induced by lime in aqueous media, burnt dolomitic lime is obviously void of any genotoxic potential.
Classification for genotoxicity is not warranted.
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