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Diss Factsheets
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EC number: 229-912-9 | CAS number: 6834-92-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- yes
- Remarks:
- 1-fluoro-2,4-dinitrobenzene (DNFB) as positive control
- GLP compliance:
- not specified
- Type of study:
- mouse local lymph node assay (LLNA)
- Species:
- mouse
- Strain:
- Balb/c
- Sex:
- female
- Details on test animals and environmental conditions:
- TEST ANIMALS:
- Source: National Cancer Institute, USA
- Age: 45 - 60 days
- Weight at study initiation: 17 - 20 g - Vehicle:
- other: 15% ethanol
- Concentration:
- 2, 4 and 6%
- Details on study design:
- RANGE FINDING TESTS:
- Irritation: A primary irritancy assay was performed to establish the minimal irritating and the maximal non-irritating concentration.
TREATMENT PREPARATION AND ADMINISTRATION:
Test solutions were prepared daily in amber vials using 15% ethanol. - Positive control substance(s):
- other: 1-fluoro-2,4-dinitrobenzene (DNFB)
- Statistics:
- Bartlett's chi-square Test, one-way ANOVA and Dunnett's Multiple Range t Test
- Parameter:
- SI
- Remarks on result:
- other: no data
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Method not validated; unsuitable test system. The MEST failed to prove as a valid test in the validation process (ECETOC Technical Report No. 78, 1999).
- Principles of method if other than guideline:
- Method: other: MEST
- GLP compliance:
- not specified
- Type of study:
- mouse ear swelling test
- Species:
- mouse
- Vehicle:
- other: 15% ethanol
- Vehicle:
- other: 15% ethanol
- Details on study design:
- 1st application: Induction 4 % open epicutaneous
2nd application: Challenge 6 % open epicutaneous - Interpretation of results:
- sensitising
- Remarks:
- Migrated information
Referenceopen allclose all
RESULTS OF PILOT STUDY: minimal irritating concentration: 6%; maximal non-irritating concentration: 4%
RESULTS OF TEST
- Sensitization reaction: sensitization with 2-6% did not significantly alter cell proliferation in the auricular lymph nodes,
even though an increase of 30% and 40% at the 4% and 6% treatment levels was measured, respectively. A greater than
30-fold increase was measured in the positive control.
RS-Freetext:
RESULTS OF PILOT STUDY: minimal irritating concentration: 6%; maximal non-irritating concentration: 4%
RESULTS OF TEST
- Sensitization reaction: 15% increase in ear swelling 48 h after challenge for mice that were sensitized with 4% metasilicate. 28% increase with positive control. According to the authors sodium metasilicate is a weak sensitizer in this test system.
- Clinical signs: not reported
- Rechallenge: not performed
Endpoint conclusion
- Additional information:
Disodium metasilicate was not sensitizing in the local lymph node assay. In a human case report, contact urticaria induced by sodium silicate was observed in one individual.
Migrated from Short description of key information:
Disodium metasilicate is not sensitising (LLNA).
Respiratory sensitisation
Endpoint conclusion
- Additional information:
Not required. No data available.
.
Justification for classification or non-classification
The available data is conclusive but not sufficient for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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