Registration Dossier
Registration Dossier
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EC number: 215-199-1 | CAS number: 1312-76-1
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Low potential for bioaccumulation.
Key value for chemical safety assessment
Additional information
Toxicokinetic data on vertebrates revealed a low potential for bioaccumulation. Ingested soluble silicates are excreted via urine and to a lesser extent via the faeces. Markedly increased and rapid urinary excretion of silica was observed when soluble sodium silicates were administered to rats (Benke & Osborn 1979), dogs (King et al. 1933), cats (King & McGeorge 1938) and guinea pigs (Sauer et al. 1959). The urinary silicon excretion half-life after administration of sodium silicate to rats via stomach tube was 24 h (Benke & Osborn 1979).
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