Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-633-8 | CAS number: 144-55-8
Endpoint summary
Administrative data
Description of key information
Oral LD50 > 4000 mg/kg bw/d.
Inhalation LC50 > 4.74 mg/L.
Key value for chemical safety assessment
Additional information
The LD50 studies presented indicate low acute oral toxicity in rats, with LD50 values varying from >4,000 mg/kg bw up to 7,334 mg/kg bw. Considering the history of human use of sodium bicarbonate, the effects of oral exposure are well known due to accidental and intentional ingestion by humans, and it is considered safe to ingest up to 4 g/dose.
The inhalation toxicity study indicated a low toxic potential, as the LC50 was >4.74 mg/L.
[partly taken from OECD SIDS on sodium bicarbonate (2002), pg. 15]
Justification for classification or non-classification
Based on the results described, the substance does not need to be classified for acute toxicity according to CLP Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
