Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-619-1 | CAS number: 144-19-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The mutagenic/genotoxic potential of 2,2,4-trimethyl-1,3-pentanediol has been characterized in well-conducted in vitro bacterial (AMES) and mammalian cell (mouse lymphoma) mutagenicity assays and an in vitro chromosomal aberration assay. All 3 studies were conducted according to current OECD Guidelines and are considered to be key studies.
In a bacterial reverse gene mutation assay conducted according to OECD Guideline 471, there was no increase in cytotoxicity or mutation frequency in any strain of Salmonella typhimurium or Escherichia coli at concentrations up to 5000 µg/plate in the presence or absence of metabolic activation.
In a mammalian mutagenicity assay conducted according to OECD Guideline 476 using an L5178Y mouse lymphoma cell line, there were no increases in the mutation frequency at the thymidine kinase locus, either with or without metaboic activation.
In an in vitro chromosome aberration assay conducted according to OECD Guideline 472, there was no increase in chromosome aberrations or polyploidy in Chinese Hamster Ovary cells tested at concentrations up to 1500 µg/mL in the presence and absence of metabolic activation, even at concentrations that caused cytotoxicity. In all studies, vehicle, negative and positive controls induced the appropriate responses.
Endpoint Conclusion:
Justification for classification or non-classification
Although no in vitro or in vivo germ cell mutagenicity/genotoxicity studies were available for review, the total weight-of-the-evidence from 3 independent in vitro studies indicates that 2,2,4-trimethyl-1,3-pentanediol is not expected to induce heritable mutations in the germ cells of humans and is not classified for mutagenicity/genotoxicity according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008 or UN Globally Harmonized System of Classification and Labelling of Chemicals (GHS). 2,2,4-Trimethyl-1,3-pentanediol is not classified for mutagenicity/genotoxicity according to Annex I of Directive 67/548/EEC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.