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Registration Dossier
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EC number: 266-002-0 | CAS number: 65996-69-2 The fused substance formed by the action of a flux upon the gangue of the iron-bearing materials charged to a blast furnace and upon the oxidized impurities in the iron produced. Depending upon the particular blast furnace operation, the slag is composed primarily of sulfur and oxides of aluminum, calcium, magnesium, and silicon.
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, basic data given
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- guideline used
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Slags, ferrous metal, blast furnace
- EC Number:
- 266-002-0
- EC Name:
- Slags, ferrous metal, blast furnace
- Cas Number:
- 65996-69-2
- Molecular formula:
- ~ Al(n)Ca(m)Mg(o)Si(p)O(3n/2+m+o+2p)
- IUPAC Name:
- Aluminium-Calcium-Magnesium-Silicium oxide equivalent
- Reference substance name:
- slag, ferrous metal, blast furnace
- IUPAC Name:
- slag, ferrous metal, blast furnace
- Reference substance name:
- ABS
- IUPAC Name:
- ABS
- Details on test material:
- Air-cooled blast furnace slag [crystalline] (ABS, Hochofenstueckschlacke HOS according to DIN 4301)
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- animals kept at 12 h light /dark cycle at 22+/-3 °C
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- unchanged (no vehicle)
- Doses:
- >2000 mg/kg bw
- No. of animals per sex per dose:
- not reported
- Control animals:
- not specified
- Details on study design:
- Observation period of 14 d after incubation
- Statistics:
- not relevant since no observable effect
Results and discussion
- Preliminary study:
- not reported
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no effects on all test animals
- Mortality:
- no mortality
- Clinical signs:
- other: no clinical signs
- Gross pathology:
- no findings rfeported
- Other findings:
- no other findings reported
Any other information on results incl. tables
In an acute toxicity test according to OECD TG 401 with Wistar rats, no effect of air-cooled blast furnace slag was observed in a limit test at 2000 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- other: not toxic
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- ABS rats OECD 401: LD0 >= 2000 mg/kg bw
LD50 > 2000 mg/kg bw - Executive summary:
In an acute toxicity test according to OECD TG 401 with Wistar rats, no effect of air-cooled blast furnace slag (ABS) was observed in a limit test at 2000 mg/kg bw (Hygiene-Institut (Sauerwald) 2000)
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