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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2002
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study, basic data given

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2002
Report Date:
2002

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
Principles of method if other than guideline:
guideline used
GLP compliance:
not specified
Test type:
acute toxic class method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Type:
Constituent
Details on test material:
Air-cooled blast furnace slag [crystalline] (ABS, Hochofenstueckschlacke HOS according to DIN 4301)

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals and environmental conditions:
animals kept at 12 h light /dark cycle at 22+/-3 °C

Administration / exposure

Route of administration:
oral: feed
Vehicle:
unchanged (no vehicle)
Doses:
>2000 mg/kg bw
No. of animals per sex per dose:
not reported
Control animals:
not specified
Details on study design:
Observation period of 14 d after incubation
Statistics:
not relevant since no observable effect

Results and discussion

Preliminary study:
not reported
Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: no effects on all test animals
Mortality:
no mortality
Clinical signs:
no clinical signs
Body weight:
no efffect on body weight
Gross pathology:
no findings rfeported
Other findings:
no other findings reported

Any other information on results incl. tables

In an acute toxicity test according to OECD TG 401 with Wistar rats, no effect of air-cooled blast furnace slag was observed in a limit test at 2000 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
other: not toxic
Remarks:
Criteria used for interpretation of results: EU
Conclusions:
ABS rats OECD 401: LD0 >= 2000 mg/kg bw
LD50 > 2000 mg/kg bw
Executive summary:

In an acute toxicity test according to OECD TG 401 with Wistar rats, no effect of air-cooled blast furnace slag (ABS) was observed in a limit test at 2000 mg/kg bw (Hygiene-Institut (Sauerwald) 2000)