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EC number: 923-592-0
CAS number: -
Available data suggest that the registered substance as a whole may be absorbed to some extent following oral and inhalation routes of exposure. Some components within this complex mixture constituting the registered substance may be more absorbed more readily than other components.
No specific ADME and/or toxicokinetic data are available for the
registered substance. Following a single oral administration to rats of
both sexes at the limit dose of 2000 mg/kg no signs of systemic toxicity
were noted although some effects on body weight (slightly reduced body
weight gains in males, body weight loss in one out of the three treated
females) were observed during the first week after treatment. Similarly,
following a single dermal application of a structurally related
substance at the limit dose of 2000 mg/kg no signs of systemic toxicity
but only local irritating effects were noted. In inhalation experiments
in which mice were exposed for 2 hours to very high aerosol
concentrations, clinical signs such as reduced activity, uncoordinated
movements together with dyspnoea were noted in animals before death,
however, the LC50 was calculated to be 19 ± 1.4 mg/L, much higher than
the limit dose.
In a developmental toxicity study (Oral Gavage) in the rat (OECD 414)
there was a slight decrease in food consumption and body-weight gain.
There were also minor effects on embryofoetal development. These effects
were observed in animals tested at the highest dose level of 1000
mg/kg/day. There were no test-item-related findings upon necropsy.
These data suggest that the registered substance as a whole may be
absorbed to some extent following oral and inhalation routes of
exposure. Some components within this complex mixture constituting the
registered substance may be more absorbed more readily than other
components. Although acute dermal data gives little indication as to the
absorption through the skin, there will be at least some, because the
substance was able to penetrate to produce skin sensitisation (based on
results of a LLNA study) and animal studies with materials called "shale
oils" in the public domain evidenced a carcinogenic response following
repeated dermal applications to mice and rabbits. Although the
registered substance is irritating for both the skin and eye, these
tumours were not considered related only to local effects.
In the absence of any fully quantitative information, in line with ECHA
guidance inhalation absorption is considered to be 100 % and oral and
dermal absorption are considered to by 50 % for each of these routes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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