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EC number: 210-568-3 | CAS number: 618-88-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Short term toxicity to aquatic invertebrates:
By applying weight of evidence approach the EC 50 value of test chemical is expected to be in range from 96.7 mg/L to 103 mg/L after exposure to Daphnia magna for 48 h. This range EC 50 value indicates that the test chemical is likely to be nonhazardous to aquatic invertebrates and cannot be classified as per CLP regulation. Since the test chemical is readily biodegradable in nature.
Additional information
Short term toxicity to aquatic invertebrates:
Short term toxicity to aquatic invertebrates of test chemical was determined by using weight of evidence approach by using different experimental data from its structurally similar read across analogues and their results are summarized below
In first study an experiment was conducted to determine the short term toxicity of test chemical to aquatic invertebrates by using OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test). The test organisms used in this study was Daphnia magna. The stock solution 200 mg/l of test chemical was prepared by dissolving test chemical in reconstituted water. Test solutions of required concentrations were prepared by mixing the stock solution of the test sample with reconstituted test water. The nominal concentrations of test chemical used were 0, 6.2, 12.4, 25, 50, 100, 200 mg/l. The test system used was 50 mL glass vessel and 5 test organisms were used per vessel in 4 replicates per concentration. The experiment was carried out in static system in freshwater and various concentrations of test chemical exposed to Daphnia magna for 48 h and at temperature 20±1°C. The reference substance used was
Potassium dichromate. EC50 was calculated using nonlinear regression by the software Prism 4.0
After 48 h exposure of test chemical to Daphnia magna the effective concentration at which 50 % immobility observed EC50 value was determined to be 96.7 mg/L (95% CI was 68.6 - 136.4 mg/l). The EC50 value of reference substance was observed to be 0.76 mg/L (24 hours).
The EC 50 value indicates that the test chemical is likely to be nonhazardous to aquatic invertebrates. Since the test chemical is readily biodegradable in nature.
Another study was reviewed from Environmental Toxicology and Chemistry, 2003 in this an experiment was conducted to determine the short term toxicity of test chemical to aquatic invertebrates by using ISO 6341 (Water quality - Determination of the Inhibition of the Mobility of Daphnia magna Straus (Cladocera, Crustacea)). ). The test organisms used in this study was Daphnia magna. The Stock solution of test chemical was prepared by addition of the test chemical to MilliQ water in a measuring flask and ultrasonic bath until a total solubilization of the chemical was achieved. Range-finding experiments covered several decades of concentrations and then definitive tests was established EC values and the corresponding 95% confidence intervals. 5-8 different nominal concentration of test chemical were used in the study. The experiment was carried out in static system in freshwater and different concentrations of test chemical exposed to Daphnia magna for 48 h. The number of organisms used per vessel was 5 with 4 replicates of each concentrations. The 6 replicates of control was also used. The reference substance used was Potassium dichromate. After 48 h exposure the EC 50 value was determined by using probit analysis method.
The EC10 and EC50 value was determined to be 6.04 mg/L and 103 mg/L (95% confidence interval (85.0; 123)) respectively after exposure of test chemical to Daphnia magna for 48 h.The EC10 and EC50 value was determined to be 32.6 mg/L and 121 mg/L (95 % confidence interval (103; 141)) respectively after exposure of test chemical to Daphnia magna for 24 h.
By considering EC50 value after exposure for 48 h the test chemical is considered to be nontoxic to aquatic invertebrates and cannot be classified as per CLP regulation.
By considering results of both the studies mentioned above and applying weight of evidence approach the EC 50 value of test chemical is expected to be in range from 96.7 mg/L to 103 mg/L after exposure to Daphnia magna for 48 h. This range EC 50 value indicates that the test chemical is likely to be nonhazardous to aquatic invertebrates and cannot be classified as per CLP regulation. Since the test chemical is readily biodegradable in nature.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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